TF Info Page for ATF3 (bZIP)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785]
Entrez Summary This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Ensembl ID: ENSG00000162772
External Link: CisBP
Interpro IPR000837; IPR004827;
Protein Domain: ENSP00000336908
Protein Domain: ENSP00000344352
Protein Domain: ENSP00000355948
Protein Domain: ENSP00000355950
Protein Domain: ENSP00000355954
Protein Domain: ENSP00000480606
Domain:
Protein: ENSP00000336908DBD: bZIPOther:
Protein: ENSP00000344352DBD: bZIPOther:
Protein: ENSP00000355948DBD: bZIPOther:
Protein: ENSP00000355950DBD: bZIPOther:
Protein: ENSP00000355954DBD: bZIPOther:
Protein: ENSP00000480606DBD: bZIPOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:11916968 12815047
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000982
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IBA - GO_REF:0000033
GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IC - GO_REF:0000036
GO:0003700
sequence-specific DNA binding transcription factor activity
IGI - PMID:24939851
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqmodENCODEDirect
ChIP-seqmodENCODEDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMDREAM_contestInferred - Atf3 (98% AA Identity, Mus musculus)
PBMZoo_01Inferred - Atf3 (98% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - JDP2 (71% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - JDP2 (71% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - JDP2 (71% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - JDP2 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - JDP2 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - JDP2 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - JDP2 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - JDP2 (71% AA Identity, Homo sapiens)
PBMBadis09Inferred - Jdp2 (71% AA Identity, Mus musculus)
PBMZoo_01Inferred - Jdp2 (71% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Jdp2 (71% AA Identity, Rattus norvegicus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution