TF Info Page for LMX1A (Homeodomain)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | LIM homeobox transcription factor 1 alpha [Source:HGNC Symbol;Acc:HGNC:6653] | |||||||||
| Entrez Summary | This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] | |||||||||
| Ensembl ID: | ENSG00000162761 | |||||||||
| External Link: | CisBP | |||||||||
| Interpro | IPR001356; IPR001781; IPR009057; IPR017970; | |||||||||
| Protein Domain: | ENSP00000294816 | |||||||||
| Protein Domain: | ENSP00000340226 | |||||||||
| Protein Domain: | ENSP00000356868 | |||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
Indeterminate - There is no evidence for or against this genes role as a TF___ PMIDS:0 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |