TF Info Page for NR2F6 (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: nuclear receptor subfamily 2 group F member 6 [Source:HGNC Symbol;Acc:HGNC:7977]
Entrez Summary NA
Ensembl ID: ENSG00000160113
External Link: CisBP
Interpro IPR000536; IPR001628; IPR001723; IPR003068; IPR008946; ;
Protein Domain: ENSP00000291442
Protein Domain: ENSP00000471686
Domain:
Protein: ENSP00000291442DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000471686DBD: Nuclear Hormone ReceptorOther: Hormone_recep

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:12690040
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001227
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IEA - GO_REF:0000019
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:10644740
GO:0004879
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
TAS - PMID:2905047
GO:0004887
thyroid hormone receptor activity
TAS - PMID:2905047
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
PBMZoo_01Direct
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMDREAM_contestInferred - Nr2f6 (98% AA Identity, Mus musculus)
PBMBadis09Inferred - Nr2f2 (85% AA Identity, Mus musculus)
ChIP-seqmodENCODEInferred - NR2F2 (85% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - NR2F2 (85% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NR2F2 (85% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NR2F2 (85% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NR2F2 (85% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NR2F2 (85% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NR2F1 (84% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NR2F1 (84% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NR2F1 (84% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NR2F1 (84% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NR2F1 (84% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NR2F1 (84% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NR2F1 (84% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NR2F1 (84% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Nr2f1 (84% AA Identity, Mus musculus)
PBMZoo_01Inferred - nr2f2 (84% AA Identity, Danio rerio)
SELEXJASPARInferred - NR2F1 (84% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NR2F1 (84% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NR2F1 (84% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NR2F1 (84% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Q969A9_BOMMO (80% AA Identity, Bombyx mori)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution