TF Info Page for RUNX1 (Runt)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Description
| Description: | runt related transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10471] | ||||||||||||||||||
| Entrez Summary | NA | ||||||||||||||||||
| Ensembl ID: | ENSG00000159216 | ||||||||||||||||||
| External Link: | CisBP | ||||||||||||||||||
| Interpro | IPR000040; IPR008967; IPR013524; IPR013711; IPR016554; ; | ||||||||||||||||||
| Protein Domain: | ENSP00000300305 | ||||||||||||||||||
| Protein Domain: | ENSP00000340690 | ||||||||||||||||||
| Protein Domain: | ENSP00000351123 | ||||||||||||||||||
| Protein Domain: | ENSP00000405158 | ||||||||||||||||||
| Protein Domain: | ENSP00000382184 | ||||||||||||||||||
| Protein Domain: | ENSP00000388189 | ||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_Transactivation_ PMIDS:7609063 8035830 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:9199349 | IMP - PMID:9199349 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |