TF Info Page for ELK4 (Ets)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: ELK4, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3326]
Entrez Summary This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000158711
External Link: CisBP
Interpro IPR000418; ;
Protein Domain: ENSP00000289703
Protein Domain: ENSP00000350681
Protein Domain: ENSP00000484946
Domain:
Protein: ENSP00000289703DBD: ETSOther:
Protein: ENSP00000350681DBD: ETSOther:
Protein: ENSP00000484946DBD: ETSOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:8524663
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
GO:0003700
sequence-specific DNA binding transcription factor activity
NAS - PMID:7851904
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMWei10Inferred - Elk4 (95% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ELK3 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK3 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK3 (82% AA Identity, Homo sapiens)
PBMZoo_01Inferred - elk4 (82% AA Identity, Tetraodon nigroviridis)
TransfacTransfacLicense requiredInferred - ELK3 (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK3 (82% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk3 (81% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ELK1 (79% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK1 (79% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (79% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (79% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk1 (79% AA Identity, Mus musculus)
SELEXJASPARInferred - ELK1 (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (79% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK1 (79% AA Identity, Homo sapiens)
MiscHOMERInferred - ELK1 (79% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (61% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (61% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (61% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (61% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (61% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (61% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (61% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv4 (61% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ETV4 (61% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETV4 (61% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV4 (61% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV1 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV1 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV1 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV1 (60% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv1 (60% AA Identity, Mus musculus)
PBMWei10Inferred - Etv1 (60% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ETV5 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (60% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv5 (60% AA Identity, Mus musculus)
MiscHOMERInferred - ETV1 (60% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV5 (60% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - GABPA (59% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GABPA (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GABPA (59% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gabpa (59% AA Identity, Mus musculus)
PBMWei10Inferred - Gabpa (59% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - pnt (59% AA Identity, Drosophila melanogaster)
ChIP-seqENCODEInferred - GABPA (59% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (59% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (59% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (59% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (59% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Gabpa (59% AA Identity, Mus musculus)
MiscHocoMocoInferred - GABPA (59% AA Identity, Homo sapiens)
MiscHOMERInferred - GABPA (59% AA Identity, Homo sapiens)
PBMWei10Inferred - Ets1 (58% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ETS1B_CHICK (58% AA Identity, Gallus gallus)
HT-SELEXNitta2015Inferred - Ets96B (55% AA Identity, Drosophila melanogaster)
PBMWei10Inferred - XP_911724.4 (55% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ETV3 (54% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV3 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV3 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV3 (54% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv3 (54% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - Ets65A (53% AA Identity, Drosophila melanogaster)

Structure

Structure PDB 1BC7

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution