TF Info Page for GRHL3 (Grainyhead)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Binds the same AACCGGTT consensus as the paralog GRHL1 based on SELEX (PMID: 21081122). |
Description
| Description: | grainyhead like transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:25839] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000158055 | |
| External Link: | ||
| Interpro | IPR007604; ; | |
| Protein Domain: | ||
| Protein: ENSP00000236255 | DBD: CP2 | Other: |
| Protein: ENSP00000348333 | DBD: CP2 | Other: |
| Protein: ENSP00000354943 | DBD: CP2 | Other: |
| Protein: ENSP00000288955 | DBD: CP2 | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene Candidate_DNA-Binding sequence-specific_Transactivation_ PMIDS:12549979 15831758 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:23685552 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
3a, decent circumstantial evidence for its role as |
| TF has conditional DNA-binding requirements |