TF Info Page for SKI (Unknown)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Conflicting evidence. Binds specifically to GTCTAGAC via EMSA in one study (PMID: 9452486). But, needs to form complexes with other proteins, such as NFI, to bind to DNA in another (PMID: 9380514). Related to SKIL, which also has evidence for DNA binding (PMID: 9824161) |
Description
| Description: | SKI proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10896] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000157933 | |
| External Link: | ||
| Interpro | IPR003380; IPR009061; IPR010919; IPR014890; | |
| Protein Domain: | ||
| Protein: ENSP00000367797 | DBD: Other | Other: Ski_Sno, c-SKI_SMAD_bind |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene Candidate_Transcription Factor Binding tf co-factor binding_TF PPI_ PMIDS:12435627 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | No |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IBA - GO_REF:0000033 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
4a, two or more datasets predict it as a TF |
| TF has conditional DNA-binding requirements |