Assessment | Binding Mode | Motif Status | Notes | Comments |
---|---|---|---|---|
Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Conflicting evidence. Binds specifically to GTCTAGAC via EMSA in one study (PMID: 9452486). But, needs to form complexes with other proteins, such as NFI, to bind to DNA in another (PMID: 9380514). Related to SKIL, which also has evidence for DNA binding (PMID: 9824161) |
Description: | SKI proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10896] | |||
Entrez Summary | #!usr/local/bin/perl ?> This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009] | |||
Ensembl ID: | ENSG00000157933 | |||
External Link: | CisBP | |||
Interpro | IPR003380; IPR009061; IPR010919; IPR014890; | |||
Protein Domain: | ENSP00000367797 | |||
Domain: |
|
Source | Annotation |
TF-CAT classification |
TF Gene Candidate_Transcription Factor Binding tf co-factor binding_TF PPI_ PMIDS:12435627 |
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
CisBP considers it as a TF? | No |
TFclass considers it as a TF? | No |
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
GO-Info |
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IBA - GO_REF:0000033 |
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
4a, two or more datasets predict it as a TF |
TF has conditional DNA-binding requirements |