The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	ETS proto-oncogene 2, transcription factor [Source:HGNC Symbol;Acc:HGNC:3489]
Entrez Summary	TBA
Ensembl ID:	ENSG00000157557
External Link:
Interpro	IPR000418; IPR003118; IPR013761; IPR016311; IPR027276; ;
Protein Domain:
Protein: ENSP00000354194	DBD: ETS	Other: SAM_PNT
Protein: ENSP00000353344	DBD: ETS	Other: SAM_PNT
Protein: ENSP00000411086	DBD: ETS	Other: SAM_PNT
Protein: ENSP00000401273	DBD: ETS	Other: SAM_PNT

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:12637547 12928043
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:12637547 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:11909962
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
PBM	Wei10		Inferred - Ets1 (96% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ETS1B_CHICK (96% AA Identity, Gallus gallus)
HT-SELEX	Nitta2015		Inferred - pnt (93% AA Identity, Drosophila melanogaster)
ChIP-seq	ENCODE		Inferred - ETS1 (90% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - ETS1 (90% AA Identity, Homo sapiens)
SELEX	Hallikas2006		Inferred - ETS1 (90% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - ETS1 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS1 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS1 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS1 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS1 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS1 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS1 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS1 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS1 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS1 (90% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ETS1 (90% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ETS1 (90% AA Identity, Homo sapiens)
SMiLE-seq	Isakova2017		Inferred - GABPA (67% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - GABPA (67% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - GABPA (67% AA Identity, Homo sapiens)
PBM	Badis09		Inferred - Gabpa (67% AA Identity, Mus musculus)
PBM	Wei10		Inferred - Gabpa (67% AA Identity, Mus musculus)
ChIP-seq	ENCODE		Inferred - GABPA (67% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (67% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (67% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (67% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (67% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (67% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (67% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (67% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (67% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (67% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (67% AA Identity, Homo sapiens)
ChIP-seq	JASPAR		Inferred - Gabpa (67% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - GABPA (67% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - GABPA (67% AA Identity, Homo sapiens)
HT-SELEX	Jolma2010		Inferred - ERG (65% AA Identity, Homo sapiens)
HT-SELEX	Jolma2010		Inferred - ERG (65% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (65% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (65% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (65% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (65% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (65% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (65% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (65% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (65% AA Identity, Homo sapiens)
HT-SELEX	Nitta2015		Inferred - Ets65A (65% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - ETV1 (65% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV1 (65% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV1 (65% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV1 (65% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv1 (65% AA Identity, Mus musculus)
PBM	Wei10		Inferred - Etv1 (65% AA Identity, Mus musculus)
SELEX	JASPAR		Inferred - ERG (65% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ERG (65% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ERG (65% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ERG (65% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ERG (65% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ETV1 (65% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK1 (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK1 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK1 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK1 (64% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Elk1 (64% AA Identity, Mus musculus)
PBM	Wei10		Inferred - Erg (64% AA Identity, Mus musculus)
HT-SELEX	Nitta2015		Inferred - Ets21C (64% AA Identity, Drosophila melanogaster)
PBM	Zoo_01		Inferred - Ets21C (64% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - ETV5 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV5 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV5 (64% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv5 (64% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - FEV (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FEV (64% AA Identity, Homo sapiens)
SMiLE-seq	Isakova2017		Inferred - FLI1 (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (64% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Fli1 (64% AA Identity, Mus musculus)
SELEX	JASPAR		Inferred - ELK1 (64% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (64% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (64% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (64% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (64% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (64% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - FLI1 (64% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - FLI1 (64% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - FLI1 (64% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ELK1 (64% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ELK1 (64% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ETV5 (64% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - FEV (64% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - FLI1 (64% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Fli1 (64% AA Identity, Mus musculus)
HT-SELEX	Nitta2015		Inferred - Ets96B (63% AA Identity, Drosophila melanogaster)
PBM	Zoo_01		Inferred - elk4 (62% AA Identity, Tetraodon nigroviridis)
HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv4 (62% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ETV4 (62% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETV4 (62% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ETV4 (62% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV2 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV2 (60% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETV2 (60% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Elk3 (59% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ELK3 (59% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK4 (58% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK4 (58% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK4 (58% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Elk4 (58% AA Identity, Mus musculus)
PBM	Wei10		Inferred - XP_911724.4 (58% AA Identity, Mus musculus)
ChIP-seq	ENCODE		Inferred - ELK4 (58% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - ELK4 (58% AA Identity, Homo sapiens)
ChIP-seq	JASPAR		Inferred - ELK4 (58% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK4 (58% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK4 (58% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ELK4 (58% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV3 (56% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV3 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV3 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV3 (56% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv3 (56% AA Identity, Mus musculus)

Structure

Structure	PDB	4BQA

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 443, "endStyle": "curved", "aliStart": 364, "text": "Ets", "colour": "#009900", "aliEnd": 443, "start": 364, "href": "http://pfam.xfam.org/family/PF00178.20", "type": "pfama", "display": "true", "metadata": {"end": 443, "description": "The ETS domain is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence. ", "database": "PfamA", "aliStart": 364, "scoreName": "E-value", "accession": "PF00178.20", "start": 364, "score": 1.3999999999999999e-36, "identifier": "Ets-domain", "type": "DBD", "aliEnd": 443}}, {"startStyle": "straight", "end": 170, "endStyle": "straight", "aliStart": 88, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 169, "start": 87, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 170, "description": NaN, "database": "PfamA", "aliStart": 88, "scoreName": "E-value", "accession": "PF02198.14", "start": 87, "score": 8e-33, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 169}}], "length": 470}

TF Info Page for ETS2 (Ets)