TF Info Page for ERG (Ets)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: ERG, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3446]
Entrez Summary This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Ensembl ID: ENSG00000157554
External Link: CisBP
Interpro IPR000418; IPR003118; IPR013761; ;
Protein Domain: ENSP00000288319
Protein Domain: ENSP00000381871
Protein Domain: ENSP00000381877
Protein Domain: ENSP00000381891
Protein Domain: ENSP00000414150
Protein Domain: ENSP00000396268
Domain:
Protein: ENSP00000288319DBD: ETSOther: SAM_PNT
Protein: ENSP00000381871DBD: ETSOther: SAM_PNT
Protein: ENSP00000381877DBD: ETSOther: SAM_PNT
Protein: ENSP00000381891DBD: ETSOther: SAM_PNT
Protein: ENSP00000414150DBD: ETSOther: SAM_PNT
Protein: ENSP00000396268DBD: ETSOther: SAM_PNT

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2010Direct
HT-SELEXJolma2010Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
SELEXJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMWei10Inferred - Erg (98% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - FLI1 (97% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (97% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (97% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (97% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (97% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (97% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (97% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (97% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (97% AA Identity, Homo sapiens)
PBMWei10Inferred - Fli1 (97% AA Identity, Mus musculus)
SELEXJASPARInferred - FLI1 (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (97% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FLI1 (97% AA Identity, Homo sapiens)
MiscHOMERInferred - Fli1 (97% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - Ets65A (96% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Ets21C (86% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - Ets21C (86% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - FEV (86% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FEV (86% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FEV (86% AA Identity, Homo sapiens)
PBMWei10Inferred - Ets1 (64% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - pnt (64% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - ETS1B_CHICK (64% AA Identity, Gallus gallus)
HT-SELEXYin2017Inferred - ETV1 (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV1 (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV1 (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV1 (58% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv1 (58% AA Identity, Mus musculus)
PBMWei10Inferred - Etv1 (58% AA Identity, Mus musculus)
MiscHOMERInferred - ETV1 (58% AA Identity, Homo sapiens)
PBMZoo_01Inferred - elk4 (55% AA Identity, Tetraodon nigroviridis)
HT-SELEXYin2017Inferred - ETV5 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (55% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv5 (55% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - GABPA (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GABPA (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GABPA (55% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gabpa (55% AA Identity, Mus musculus)
PBMWei10Inferred - Gabpa (55% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Gabpa (55% AA Identity, Mus musculus)
MiscHocoMocoInferred - ETV5 (55% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GABPA (55% AA Identity, Homo sapiens)
MiscHOMERInferred - GABPA (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK1 (54% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK1 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (54% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk1 (54% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - Ets96B (54% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - ETV4 (54% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (54% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (54% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv4 (54% AA Identity, Mus musculus)
SELEXJASPARInferred - ELK1 (54% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (54% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (54% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (54% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (54% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (54% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETV4 (54% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETV4 (54% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK1 (54% AA Identity, Homo sapiens)
MiscHOMERInferred - ELK1 (54% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV4 (54% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk4 (53% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ETV2 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV2 (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV3 (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV3 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV3 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV3 (53% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv3 (53% AA Identity, Mus musculus)
PBMWei10Inferred - XP_911724.4 (53% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ETV2 (53% AA Identity, Homo sapiens)

Structure

Structure PDB 4IRI

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution