The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif		Crystral structure available (PMID: 20430012)

Description

Description:	mitochondrial transcription termination factor 3 [Source:HGNC Symbol;Acc:HGNC:24258]
Entrez Summary	TBA
Ensembl ID:	ENSG00000156469
External Link:
Interpro	IPR003690; ;
Protein Domain:
Protein: ENSP00000287025	DBD: mTERF	Other: Pex14_N
Protein: ENSP00000429400	DBD: mTERF	Other: Pex14_N
Protein: ENSP00000430138	DBD: mTERF	Other:
Protein: ENSP00000429526	DBD: mTERF	Other:
Protein: ENSP00000429267	DBD: mTERF	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	No
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "jagged", "end": 399, "endStyle": "curved", "aliStart": 155, "text": "mTERF", "colour": "#2cb42c", "aliEnd": 398, "start": 125, "href": "http://pfam.xfam.org/family/PF02536.12", "type": "pfama", "display": "true", "metadata": {"end": 399, "description": "This family contains one sequence of known function  Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer [1].  The leucine zippers are not implicated in a dimerisation role as in other leucine zippers [1].", "database": "PfamA", "aliStart": 155, "scoreName": "E-value", "accession": "PF02536.12", "start": 125, "score": 1.9e-29, "identifier": "mTERF", "type": "DBD", "aliEnd": 398}}, {"startStyle": "jagged", "end": 163, "endStyle": "jagged", "aliStart": 68, "text": "Pex14_N", "colour": "#9999ff", "aliEnd": 149, "start": 24, "href": "http://pfam.xfam.org/family/PF04695.11", "type": "pfama", "display": "true", "metadata": {"end": 163, "description": "Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes.  Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein [1,2].", "database": "PfamA", "aliStart": 68, "scoreName": "E-value", "accession": "PF04695.11", "start": 24, "score": 0.0048, "identifier": "Peroxisomal membrane anchor protein (Pex14p) conserved region", "type": "DBD", "aliEnd": 149}}], "length": 418}

{"regions": [{"startStyle": "jagged", "end": 359, "endStyle": "jagged", "aliStart": 154, "text": "mTERF", "colour": "#2cb42c", "aliEnd": 356, "start": 125, "href": "http://pfam.xfam.org/family/PF02536.12", "type": "pfama", "display": "true", "metadata": {"end": 359, "description": "This family contains one sequence of known function  Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer [1].  The leucine zippers are not implicated in a dimerisation role as in other leucine zippers [1].", "database": "PfamA", "aliStart": 154, "scoreName": "E-value", "accession": "PF02536.12", "start": 125, "score": 3.3e-27, "identifier": "mTERF", "type": "DBD", "aliEnd": 356}}, {"startStyle": "jagged", "end": 163, "endStyle": "jagged", "aliStart": 68, "text": "Pex14_N", "colour": "#9999ff", "aliEnd": 149, "start": 24, "href": "http://pfam.xfam.org/family/PF04695.11", "type": "pfama", "display": "true", "metadata": {"end": 163, "description": "Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes.  Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein [1,2].", "database": "PfamA", "aliStart": 68, "scoreName": "E-value", "accession": "PF04695.11", "start": 24, "score": 0.003, "identifier": "Peroxisomal membrane anchor protein (Pex14p) conserved region", "type": "DBD", "aliEnd": 149}}], "length": 362}

TF Info Page for MTERF3 (mTERF)