The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain

Description

Description:	BTB domain and CNC homolog 1 [Source:HGNC Symbol;Acc:HGNC:935]
Entrez Summary	TBA
Ensembl ID:	ENSG00000156273
External Link:	T025299_1.02
Interpro	IPR000210; IPR004826; IPR004827; IPR008917; IPR011333; IPR013069;
Protein Domain:
Protein: ENSP00000286800	DBD: bZIP	Other: BTB
Protein: ENSP00000382805	DBD: bZIP	Other: BTB
Protein: ENSP00000408605	DBD: bZIP	Other: BTB
Protein: ENSP00000448663	DBD: bZIP	Other:
Protein: ENSP00000447332	DBD: bZIP	Other:
Protein: ENSP00000448982	DBD: bZIP	Other:
Protein: ENSP00000449316	DBD: bZIP	Other:
Protein: ENSP00000392202	DBD: bZIP	Other: BTB
Protein: ENSP00000400576	DBD: bZIP	Other: BTB
Protein: ENSP00000470673	DBD: bZIP	Other:
Protein: ENSP00000449383	DBD: bZIP	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:10620011
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:12511571 \| IMP - PMID:21555518 GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv IEA - GO_REF:0000019 GO:0001206 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv IEA - GO_REF:0000019 GO:0003700 sequence-specific DNA binding transcription factor activity ISS - GO_REF:0000024
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
ChIP-seq	modENCODE		Direct
ChIP-seq	modENCODE		Direct
ChIP-seq	modENCODE		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
Misc	HOMER		Direct
HT-SELEX	Yin2017		Inferred - BACH2 (68% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - BACH2 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - BACH2 (68% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - BACH2 (68% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - BACH2 (68% AA Identity, Homo sapiens)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for BACH1 (bZIP)