The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:

Kruppel like factor 10 [Source:HGNC Symbol;Acc:HGNC:11810]

Entrez Summary

This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Ensembl ID:

ENSG00000155090

External Link:

CisBP

Interpro

IPR007087; IPR015880;

Protein Domain:

ENSP00000285407

Protein Domain:

ENSP00000379222

Domain:

Protein: ENSP00000285407	DBD: C2H2 ZF Containing Proteins	Other: AAA_33
Protein: ENSP00000379222	DBD: C2H2 ZF Containing Proteins	Other: AAA_33

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:15087465
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:10816551, PMID:9748269
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
ChIP-seq	Najafabadi2015		Direct
ChIP-seq	Schmitges2016		Direct
PBM	Barrera2016		Inferred - KLF11 (81% AA Identity, Homo sapiens)
PBM	Barrera2016		Inferred - KLF11 (81% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - KLF11 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - KLF11 (81% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - KLF11 (81% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - KLF13 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - KLF13 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - KLF13 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - KLF13 (70% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ENSG00000275746 (70% AA Identity, Homo sapiens)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for KLF10 (C2H2 ZF(non-KRAB))