The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro		X-ray structure (PDB:3QMI) indicates sequence specific binding through base contacts (PMID: 21407193).

Description

Description:	CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343]
Entrez Summary	TBA
Ensembl ID:	ENSG00000154832
External Link:
Interpro	IPR001965; IPR002857; IPR011011; IPR019786; IPR019787; IPR022056;
Protein Domain:
Protein: ENSP00000285106	DBD: CxxC	Other: PHD, zf-CpG_bind_C
Protein: ENSP00000390475	DBD: CxxC	Other: PHD, zf-CpG_bind_C
Protein: ENSP00000467634	DBD: CxxC	Other: PHD, zf-CpG_bind_C
Protein: ENSP00000468038	DBD: CxxC	Other: PHD, PHD_2
Protein: ENSP00000465849	DBD: CxxC	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	other
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
PBM	Zoo_01		Direct
Misc	HocoMoco		Direct
PBM	Zoo_01		Inferred - BAD93120.1 (100% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - CXXC1 (100% AA Identity, Homo sapiens)

Structure

Structure	PDB	3QMI

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for CXXC1 (CxxC)