TF Info Page for CXXC1 (CxxC)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro X-ray structure (PDB:3QMI) indicates sequence specific binding through base contacts (PMID: 21407193).

Description

Description: CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343]
Entrez Summary This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]
Ensembl ID: ENSG00000154832
External Link: CisBP
Interpro IPR001965; IPR002857; IPR011011; IPR019786; IPR019787; IPR022056;
Protein Domain: ENSP00000285106
Protein Domain: ENSP00000390475
Protein Domain: ENSP00000467634
Protein Domain: ENSP00000468038
Protein Domain: ENSP00000465849
Domain:
Protein: ENSP00000285106DBD: CxxCOther: PHD, zf-CpG_bind_C
Protein: ENSP00000390475DBD: CxxCOther: PHD, zf-CpG_bind_C
Protein: ENSP00000467634DBD: CxxCOther: PHD, zf-CpG_bind_C
Protein: ENSP00000468038DBD: CxxCOther: PHD, PHD_2
Protein: ENSP00000465849DBD: CxxCOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
other
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMZoo_01Direct
MiscHocoMocoDirect
PBMZoo_01Inferred - BAD93120.1 (100% AA Identity, Homo sapiens)
MiscHocoMocoInferred - CXXC1 (100% AA Identity, Homo sapiens)

Structure

Structure PDB 3QMI

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution