TF Info Page for GABPA (Ets)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: GA binding protein transcription factor alpha subunit [Source:HGNC Symbol;Acc:HGNC:4071]
Entrez Summary This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]
Ensembl ID: ENSG00000154727
External Link: CisBP
Interpro IPR000418; IPR003118; IPR013761; IPR016312; IPR024668; IPR029071;
Protein Domain: ENSP00000346886
Protein Domain: ENSP00000382948
Domain:
Protein: ENSP00000346886DBD: ETSOther: GABP-alpha, SAM_PNT
Protein: ENSP00000382948DBD: ETSOther: GABP-alpha, SAM_PNT

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:10773883 15361867
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:12750007
GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IDA - PMID:22306510
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:7590737, PMID:8441384
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
SMiLE-seqIsakova2017Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMBadis09Inferred - Gabpa (100% AA Identity, Mus musculus)
PBMWei10Inferred - Gabpa (100% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - Gabpa (100% AA Identity, Mus musculus)
PBMWei10Inferred - Ets1 (68% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ETS1B_CHICK (68% AA Identity, Gallus gallus)
HT-SELEXNitta2015Inferred - pnt (67% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - ELK1 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK1 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (60% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk1 (60% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ELK3 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK3 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK3 (60% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk3 (60% AA Identity, Mus musculus)
PBMZoo_01Inferred - elk4 (60% AA Identity, Tetraodon nigroviridis)
SELEXJASPARInferred - ELK1 (60% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (60% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (60% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (60% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (60% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (60% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK3 (60% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK1 (60% AA Identity, Homo sapiens)
MiscHOMERInferred - ELK1 (60% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK3 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK4 (59% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK4 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK4 (59% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk4 (59% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - ELK4 (59% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - ELK4 (59% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - ELK4 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK4 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK4 (59% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK4 (59% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - Ets65A (57% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - ETV1 (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV1 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV1 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV1 (56% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv1 (56% AA Identity, Mus musculus)
PBMWei10Inferred - Etv1 (56% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ETV4 (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (56% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv4 (56% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ETV5 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (56% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv5 (56% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ETV4 (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETV4 (56% AA Identity, Homo sapiens)
MiscHOMERInferred - ETV1 (56% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV4 (56% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV5 (56% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - ERG (55% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - ERG (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (55% AA Identity, Homo sapiens)
PBMWei10Inferred - Erg (55% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - Ets21C (55% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - Ets21C (55% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - FEV (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FEV (55% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
PBMWei10Inferred - Fli1 (55% AA Identity, Mus musculus)
SELEXJASPARInferred - ERG (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ERG (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ERG (55% AA Identity, Homo sapiens)
SELEXJASPARInferred - FLI1 (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (55% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ERG (55% AA Identity, Homo sapiens)
MiscHOMERInferred - ERG (55% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FEV (55% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FLI1 (55% AA Identity, Homo sapiens)
MiscHOMERInferred - Fli1 (55% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - Ets96B (54% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - ETV2 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV2 (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETV2 (53% AA Identity, Homo sapiens)

Structure

Structure PDB 1AWC

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution