TF Info Page for TCF7L1 (HMG/Sox)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: transcription factor 7 like 1 [Source:HGNC Symbol;Acc:HGNC:11640]
Entrez Summary This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]
Ensembl ID: ENSG00000152284
External Link: CisBP
Interpro IPR009071; IPR013558;
Protein Domain: ENSP00000282111
Protein Domain: ENSP00000388984
Domain:
Protein: ENSP00000282111DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000388984DBD: HMGOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:2493990 14627819
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
NAS - PMID:11085512, PMID:1741298
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
PBMBadis09Inferred - Tcf7l1 (98% AA Identity, Mus musculus)
PBMBadis09Inferred - Tcf7l2 (92% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - TCF7L2 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TCF7L2 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TCF7L2 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TCF7L2 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TCF7L2 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TCF7L2 (92% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TCF7L2 (92% AA Identity, Homo sapiens)
MiscHOMERInferred - TCF7L2 (92% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution