TF Info Page for THRB (Nuclear receptor)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: thyroid hormone receptor beta [Source:HGNC Symbol;Acc:HGNC:11799]
Entrez Summary The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000151090
External Link: CisBP
Interpro IPR000536; IPR001628; IPR001723; IPR001728; IPR008946; ;
Protein Domain: ENSP00000348827
Protein Domain: ENSP00000404898
Protein Domain: ENSP00000395362
Protein Domain: ENSP00000388467
Protein Domain: ENSP00000414910
Protein Domain: ENSP00000414444
Protein Domain: ENSP00000393932
Protein Domain: ENSP00000414100
Protein: ENSP00000348827DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000404898DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000395362DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000388467DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000414910DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000414444DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000393932DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000414100DBD: Nuclear Hormone ReceptorOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
PMIDS:1648450 1648451
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
NAS - PMID:1618799
thyroid hormone receptor activity
IDA - PMID:15466465
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredInferred - THRA (87% AA Identity, Homo sapiens)
MiscHocoMocoInferred - THRA (87% AA Identity, Homo sapiens)
MiscHocoMocoInferred - THRA (87% AA Identity, Homo sapiens)
MiscHOMERInferred - Thra (87% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - GAG_AVIER (86% AA Identity, Avian erythroblastosis virus)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution