TF Info Page for THRB (Nuclear receptor)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | thyroid hormone receptor beta [Source:HGNC Symbol;Acc:HGNC:11799] | ||||||||||||||||||||||||
| Entrez Summary | The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008] | ||||||||||||||||||||||||
| Ensembl ID: | ENSG00000151090 | ||||||||||||||||||||||||
| External Link: | CisBP | ||||||||||||||||||||||||
| Interpro | IPR000536; IPR001628; IPR001723; IPR001728; IPR008946; ; | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000348827 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000404898 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000395362 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000388467 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000414910 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000414444 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000393932 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000414100 | ||||||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:1648450 1648451 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:1618799 GO:0004887 thyroid hormone receptor activity IDA - PMID:15466465 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |