TF Info Page for HMGA2 (AT hook)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source


Description: high mobility group AT-hook 2 [Source:HGNC Symbol;Acc:HGNC:5009]
Entrez Summary This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000149948
External Link: CisBP
Interpro IPR000116; IPR000637; IPR017956; IPR020478;
Protein Domain: ENSP00000346658
Protein Domain: ENSP00000377206
Protein Domain: ENSP00000384026
Protein Domain: ENSP00000407306
Protein Domain: ENSP00000437621
Protein Domain: ENSP00000439317
Protein Domain: ENSP00000377205
Protein: ENSP00000346658DBD: AT hookOther:
Protein: ENSP00000377206DBD: AT hookOther:
Protein: ENSP00000384026DBD: AT hookOther:
Protein: ENSP00000407306DBD: AT hookOther:
Protein: ENSP00000437621DBD: AT hookOther:
Protein: ENSP00000439317DBD: AT hookOther:
Protein: ENSP00000377205DBD: AT hookOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:18832382
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:14627817
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
PBMZoo_01Inferred - ENSPPYG00000004736 (92% AA Identity, Pongo abelii)
PBMDREAM_contestInferred - Hmga2 (92% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - HMGA1 (74% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HMGA1 (74% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HMGA1 (74% AA Identity, Homo sapiens)
PBMTF_EvolutionUnpublished DataInferred - TVAG_474020 (57% AA Identity, Trichomonas vaginalis)
PBMZoo_01Inferred - ANIA_01690 (56% AA Identity, Aspergillus nidulans)
PBMTF_EvolutionUnpublished DataInferred - FGRRES_17512 (56% AA Identity, Fusarium graminearum)
PBMTF_EvolutionUnpublished DataInferred - FGRRES_05233 (53% AA Identity, Fusarium graminearum)
TransfacTransfacLicense requiredInferred - Q7DLU9_PEA (53% AA Identity, Pisum sativum)
PBMZoo_01Inferred - BRADI3G55950 (46% AA Identity, Brachypodium distachyon)
PBMZoo_01Inferred - OS02G0824300 (46% AA Identity, Oryza sativa)
PBMBadis08Inferred - SUM1 (44% AA Identity, Saccharomyces cerevisiae)
PBMZoo_01Inferred - AHL13 (42% AA Identity, Arabidopsis thaliana)
PBMZoo_01Inferred - NCU05635 (41% AA Identity, Neurospora crassa)
PBMZoo_01Inferred - VIT_08s0007g04020 (40% AA Identity, Vitis vinifera)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution