TF Info Page for TCF7L2 (HMG/Sox)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer 100 perc ID - in vitro

Description

Description: transcription factor 7 like 2 [Source:HGNC Symbol;Acc:HGNC:11641]
Entrez Summary This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Ensembl ID: ENSG00000148737
External Link: CisBP
Interpro IPR009071; IPR013558;
Protein Domain: ENSP00000344823
Protein Domain: ENSP00000347949
Protein Domain: ENSP00000348274
Protein Domain: ENSP00000358404
Protein Domain: ENSP00000443626
Protein Domain: ENSP00000446238
Protein Domain: ENSP00000446172
Protein Domain: ENSP00000444972
Protein Domain: ENSP00000440547
Protein Domain: ENSP00000486891
Protein Domain: ENSP00000487507
Protein Domain: ENSP00000490260
Protein Domain: ENSP00000345640
Protein Domain: ENSP00000358396
Protein Domain: ENSP00000490478
Domain:
Protein: ENSP00000344823DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000347949DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000348274DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000358404DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000443626DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000446238DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000446172DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000444972DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000440547DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000486891DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000487507DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000490260DBD: HMGOther:
Protein: ENSP00000345640DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000358396DBD: HMGOther: CTNNB1_binding
Protein: ENSP00000490478DBD: HMGOther: CTNNB1_binding

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate__Other_
PMIDS:12861022 15576399 9727977 15060161 15576399
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:9727977
GO:0043433
negative regulation of sequence-specific DNA binding transcription factor activity
IDA - PMID:12799378
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMBadis09Inferred - Tcf7l2 (100% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - LEF1 (98% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - LEF1 (98% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - LEF1 (98% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - LEF1 (98% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - LEF1 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - LEF1 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - LEF1 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - LEF1 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - LEF1 (98% AA Identity, Homo sapiens)
PBMBadis09Inferred - Lef1 (98% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - TCF7 (98% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TCF7 (98% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TCF7 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF7 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF7 (98% AA Identity, Homo sapiens)
PBMBadis09Inferred - Tcf7 (98% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - LEF1 (98% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - LEF1 (98% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - LEF1 (98% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - LEF1 (98% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TCF7 (98% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TCF7 (98% AA Identity, Homo sapiens)
MiscHocoMocoInferred - LEF1 (98% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TCF7 (98% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TCF7L1 (92% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TCF7L1 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF7L1 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF7L1 (92% AA Identity, Homo sapiens)
PBMBadis09Inferred - Tcf7l1 (92% AA Identity, Mus musculus)
ChIP-chipJASPARInferred - pan (92% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - pan (92% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - pan (92% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - TCF7L1 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TCF7L1 (92% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution