The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	100 perc ID - in vitro

Description

Description:	transcription factor 7 like 2 [Source:HGNC Symbol;Acc:HGNC:11641]
Entrez Summary	TBA
Ensembl ID:	ENSG00000148737
External Link:
Interpro	IPR009071; IPR013558;
Protein Domain:
Protein: ENSP00000344823	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000347949	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000348274	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000358404	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000443626	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000446238	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000446172	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000444972	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000440547	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000486891	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000487507	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000490260	DBD: HMG	Other:
Protein: ENSP00000345640	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000358396	DBD: HMG	Other: CTNNB1_binding
Protein: ENSP00000490478	DBD: HMG	Other: CTNNB1_binding

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene Candidate__Other_ PMIDS:12861022 15576399 9727977 15060161 15576399
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:9727977 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA - PMID:12799378
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
ChIP-seq	JASPAR		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
Misc	HOMER		Direct
PBM	Badis09		Inferred - Tcf7l2 (100% AA Identity, Mus musculus)
SMiLE-seq	Isakova2017		Inferred - LEF1 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - LEF1 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - LEF1 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - LEF1 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - LEF1 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - LEF1 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - LEF1 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - LEF1 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - LEF1 (98% AA Identity, Homo sapiens)
PBM	Badis09		Inferred - Lef1 (98% AA Identity, Mus musculus)
SMiLE-seq	Isakova2017		Inferred - TCF7 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - TCF7 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - TCF7 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - TCF7 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - TCF7 (98% AA Identity, Homo sapiens)
PBM	Badis09		Inferred - Tcf7 (98% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - LEF1 (98% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - LEF1 (98% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - LEF1 (98% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - LEF1 (98% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - TCF7 (98% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - TCF7 (98% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - LEF1 (98% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - TCF7 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - TCF7L1 (92% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - TCF7L1 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - TCF7L1 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - TCF7L1 (92% AA Identity, Homo sapiens)
PBM	Badis09		Inferred - Tcf7l1 (92% AA Identity, Mus musculus)
ChIP-chip	JASPAR		Inferred - pan (92% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - pan (92% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - pan (92% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - TCF7L1 (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - TCF7L1 (92% AA Identity, Homo sapiens)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for TCF7L2 (HMG/Sox)