Binds DNA as a homodimer, recognizing a TGTCRSWWYYGWC consensus based on SELEX experiments (PMID: 22926524)
Description
Description:
NACC family member 2 [Source:HGNC Symbol;Acc:HGNC:23846];Nucleus accumbens-associated protein 2
Entrez Summary
Enables several functions, including DNA-binding transcription
repressor activity, RNA polymerase II-specific; histone deacetylase binding
activity; and protein homodimerization activity. Involved in several
processes, including negative regulation of G1/S transition of mitotic cell
cycle by negative regulation of transcription from RNA polymerase II
promoter; positive regulation of intrinsic apoptotic signaling pathway in
response to DNA damage; and protein homooligomerization. Located in
chromatin; mitochondrion; and nucleolus. [provided by Alliance of Genome
Resources, Apr 2022]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF?
No
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:22926524
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF