TF Info Page for REXO4 (Unknown)


Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 3 Low specificity DNA-binding protein No motif REXO4 (hPMC2) has been shown to bind ERE containing sequences in gel-shift experiments (PMID: 10908561) in complex with ERbeta. However, figures containing the gel-shifts have been cropped to exclude the unshifted free DNA band so it is hard to judge the evidence.


Description: REX4 homolog, 3-5 exonuclease [Source:HGNC Symbol;Acc:HGNC:12820]
Entrez Summary NA
Ensembl ID: ENSG00000148300
External Link: CisBP
Interpro IPR006055; IPR012337; IPR013520;
Protein Domain: ENSP00000361010
Protein Domain: ENSP00000361003
Protein Domain: ENSP00000391534
Protein Domain: ENSP00000394229
Protein: ENSP00000361010DBD: OtherOther: RNase_T
Protein: ENSP00000361003DBD: OtherOther: RNase_T
Protein: ENSP00000391534DBD: OtherOther:
Protein: ENSP00000394229DBD: OtherOther: RNase_T

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? No
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
NAS - PMID:10908561
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution