TF Info Page for ZNF462 (C2H2 ZF(non-KRAB))
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Has many znfC2H2 like domains that are however not in tight arrays but interspersed throughout the sequence |
Description
| Description: | zinc finger protein 462 [Source:HGNC Symbol;Acc:HGNC:21684] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000148143 | |
| External Link: | ||
| Interpro | IPR007087; IPR015880; | |
| Protein Domain: | ||
| Protein: ENSP00000277225 | DBD: C2H2 ZF Containing Proteins | Other: zf-H2C2_2, zf-H2C2_5 |
| Protein: ENSP00000405837 | DBD: C2H2 ZF Containing Proteins | Other: zf-H2C2_2, zf-H2C2_5 |
| Protein: ENSP00000397306 | DBD: C2H2 ZF Containing Proteins | Other: zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-H2C2_5 |
| Protein: ENSP00000363818 | DBD: C2H2 ZF Containing Proteins | Other: zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-H2C2_5 |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
No PMIDS: |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
b |
| CisBP considers it as a TF? | No |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
5a, one of the source datasets predicts is as a TF |
| TF has conditional DNA-binding requirements |