Contains 1 Myb domain, and has structural evidence of DNA-binding (PDB: 1IV6). Subunit of Shelterin, a complex that specifically binds telomeres (PMID: 16166375).
This gene encodes a telomere specific protein which is a component
of the telomere nucleoprotein complex. This protein is present at telomeres
throughout the cell cycle and functions as an inhibitor of telomerase, acting
in cis to limit the elongation of individual chromosome ends. The protein
structure contains a C-terminal Myb motif, a dimerization domain near its
N-terminus and an acidic N-terminus. Multiple transcripts of this gene are
alternatively spliced products. [provided by RefSeq, Aug 2022]
DBD: Myb, Myb-Like, and SANT Domain Containing Genes
Other: TRF
Protein: ENSP00000276603
DBD: Myb, Myb-Like, and SANT Domain Containing Genes
Other: TRF
Protein: ENSP00000430121
DBD: Myb, Myb-Like, and SANT Domain Containing Genes
Other: TRF
Protein: ENSP00000428838
DBD: Myb, Myb-Like, and SANT Domain Containing Genes
Other: TRF
Previous Annotations
Source
Annotation
TF-CAT classification
No PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
c
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF