nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968]
Entrez Summary
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This gene product belongs to the nuclear receptor superfamily,
members of which are transcription factors characterized by a ligand-binding
domain and a DNA-binding domain. The encoded protein is a transcriptional
regulator of the cytochrome P450 gene CYP3A4, binding to the response element
of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor
RXR. It is activated by a range of compounds that induce CYP3A4, including
dexamethasone and rifampicin. Several alternatively spliced transcripts
encoding different isoforms, some of which use non-AUG (CUG) translation
initiation codon, have been described for this gene. Additional transcript
variants exist, however, they have not been fully characterized. [provided by
RefSeq, Jul 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:11114890 GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA - PMID:12578355
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF