TF Info Page for HES6 (bHLH)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: hes family bHLH transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:18254]
Entrez Summary This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Ensembl ID: ENSG00000144485
External Link: CisBP
Interpro IPR003650; IPR011598;
Protein Domain: ENSP00000272937
Protein Domain: ENSP00000387155
Protein Domain: ENSP00000387215
Protein Domain: ENSP00000387343
Protein Domain: ENSP00000387107
Protein Domain: ENSP00000387008
Protein Domain: ENSP00000401797
Protein Domain: ENSP00000392596
Protein Domain: ENSP00000390870
Protein: ENSP00000272937DBD: bHLHOther: Hairy_orange
Protein: ENSP00000387155DBD: bHLHOther: Hairy_orange
Protein: ENSP00000387215DBD: bHLHOther:
Protein: ENSP00000387343DBD: bHLHOther: Hairy_orange
Protein: ENSP00000387107DBD: bHLHOther:
Protein: ENSP00000387008DBD: bHLHOther:
Protein: ENSP00000401797DBD: bHLHOther:
Protein: ENSP00000392596DBD: bHLHOther:
Protein: ENSP00000390870DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_Transcription Factor Binding
tf co-factor binding_TF PPI_
PMIDS:10851137 10976052
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001227
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IEA - GO_REF:0000019
sequence-specific DNA binding transcription factor activity
TAS - PMID:10851137
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution