Assessment | Binding Mode | Motif Status | Notes | Comments |
---|---|---|---|---|
Known motif | 1 Monomer or homomultimer | 100 perc ID - in vitro |
Description: | SRY-box 13 [Source:HGNC Symbol;Acc:HGNC:11192] | ||||||||||||
Entrez Summary | #!usr/local/bin/perl ?> This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12. [provided by RefSeq, Jul 2008] | ||||||||||||
Ensembl ID: | ENSG00000143842 | ||||||||||||
External Link: | CisBP | ||||||||||||
Interpro | IPR009071; ; | ||||||||||||
Protein Domain: | ENSP00000356172 | ||||||||||||
Protein Domain: | ENSP00000478239 | ||||||||||||
Protein Domain: | ENSP00000433595 | ||||||||||||
Protein Domain: | ENSP00000436297 | ||||||||||||
Domain: |
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Source | Annotation |
TF-CAT classification |
TF Gene Candidate__DNA Binding_ PMIDS:9421502 |
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
CisBP considers it as a TF? | Yes |
TFclass considers it as a TF? | Yes |
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
GO-Info |
GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:10198172 |
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
TF has conditional DNA-binding requirements |