TF Info Page for GATAD2B (GATA)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Has the full GATA domain, and JPRED4 thinks the secondary structure is preserved. The GATA domain is not sufficiently well studied to declare that specific amino acids are absolutely required in order to bind DNA. Many unusual GATA domain proteins across eukaryotes bind DNA, making it reasonable to project that this one does, too. |
Description
| Description: | GATA zinc finger domain containing 2B [Source:HGNC Symbol;Acc:HGNC:30778] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000143614 | |
| External Link: | ||
| Interpro | IPR000679; ; | |
| Protein Domain: | ||
| Protein: ENSP00000357644 | DBD: GATA | Other: P66_CC |
| Protein: ENSP00000489566 | DBD: GATA | Other: |
| Protein: ENSP00000490635 | DBD: GATA | Other: |
| Protein: ENSP00000490724 | DBD: GATA | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_Transcription Regulatory Activity heterochromatin interaction/binding_TF PPI_ PMIDS:12183469 16415179 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
x |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info |
GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000002 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
4a, two or more datasets predict it as a TF |
| TF has conditional DNA-binding requirements |