TF Info Page for SETDB1 (MBD)


Assessment Binding Mode Motif Status Notes Comments
Known motif 3 Low specificity DNA-binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Transfac motif is dubious.


Description: SET domain bifurcated 1 [Source:HGNC Symbol;Acc:HGNC:10761]
Entrez Summary This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]
Ensembl ID: ENSG00000143379
External Link: CisBP
Interpro IPR001214; IPR001739; IPR002999; IPR003606; IPR003616; IPR007728; IPR016177; IPR025796;
Protein Domain: ENSP00000271640
Protein Domain: ENSP00000357958
Protein Domain: ENSP00000357965
Protein Domain: ENSP00000436148
Protein Domain: ENSP00000432348
Protein Domain: ENSP00000407831
Protein: ENSP00000271640DBD: Methyl-CpG DNA-bindingOther: DUF4537, Pre-SET, SET
Protein: ENSP00000357958DBD: Methyl-CpG DNA-bindingOther: DUF4537
Protein: ENSP00000357965DBD: Methyl-CpG DNA-bindingOther: DUF4537, Pre-SET, SET
Protein: ENSP00000436148DBD: Methyl-CpG DNA-bindingOther: DUF4537
Protein: ENSP00000432348DBD: Methyl-CpG DNA-bindingOther: DUF4537, Pre-SET, SET
Protein: ENSP00000407831DBD: Methyl-CpG DNA-bindingOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_Transcription Factor Binding
tf co-factor binding_TF PPI_
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution