The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	3 Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Transfac motif is dubious.

Description

Description:	SET domain bifurcated 1 [Source:HGNC Symbol;Acc:HGNC:10761]
Entrez Summary	TBA
Ensembl ID:	ENSG00000143379
External Link:
Interpro	IPR001214; IPR001739; IPR002999; IPR003606; IPR003616; IPR007728; IPR016177; IPR025796;
Protein Domain:
Protein: ENSP00000271640	DBD: Methyl-CpG DNA-binding	Other: DUF4537, Pre-SET, SET
Protein: ENSP00000357958	DBD: Methyl-CpG DNA-binding	Other: DUF4537
Protein: ENSP00000357965	DBD: Methyl-CpG DNA-binding	Other: DUF4537, Pre-SET, SET
Protein: ENSP00000436148	DBD: Methyl-CpG DNA-binding	Other: DUF4537
Protein: ENSP00000432348	DBD: Methyl-CpG DNA-binding	Other: DUF4537, Pre-SET, SET
Protein: ENSP00000407831	DBD: Methyl-CpG DNA-binding	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_Transcription Factor Binding tf co-factor binding_TF PPI_ PMIDS:14536086
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	x
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
Transfac	Transfac	License required	Direct

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for SETDB1 (MBD)