TF Info Page for SETDB1 (MBD)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 3 Low specificity DNA-binding protein | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | Transfac motif is dubious. |
Description
| Description: | SET domain bifurcated 1 [Source:HGNC Symbol;Acc:HGNC:10761] | ||||||||||||||||||
| Entrez Summary | This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011] | ||||||||||||||||||
| Ensembl ID: | ENSG00000143379 | ||||||||||||||||||
| External Link: | CisBP | ||||||||||||||||||
| Interpro | IPR001214; IPR001739; IPR002999; IPR003606; IPR003616; IPR007728; IPR016177; IPR025796; | ||||||||||||||||||
| Protein Domain: | ENSP00000271640 | ||||||||||||||||||
| Protein Domain: | ENSP00000357958 | ||||||||||||||||||
| Protein Domain: | ENSP00000357965 | ||||||||||||||||||
| Protein Domain: | ENSP00000436148 | ||||||||||||||||||
| Protein Domain: | ENSP00000432348 | ||||||||||||||||||
| Protein Domain: | ENSP00000407831 | ||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_Transcription Factor Binding tf co-factor binding_TF PPI_ PMIDS:14536086 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
x |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements |