The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	nuclear receptor subfamily 1 group I member 3 [Source:HGNC Symbol;Acc:HGNC:7969]
Entrez Summary	TBA
Ensembl ID:	ENSG00000143257
External Link:	T132764_1.02
Interpro	IPR000536; IPR001628; IPR001723; IPR001728; IPR008946; ;
Protein Domain:
Protein: ENSP00000356958	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000356960	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000356961	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000356962	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000356963	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000356965	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000399361	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000412672	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000407446	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000406493	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000421374	DBD: Nuclear Hormone Receptor	Other:
Protein: ENSP00000424345	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000424934	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000422982	DBD: Nuclear Hormone Receptor	Other:
Protein: ENSP00000423666	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000427175	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000427600	DBD: Nuclear Hormone Receptor	Other:
Protein: ENSP00000426292	DBD: Nuclear Hormone Receptor	Other:
Protein: ENSP00000425417	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000421588	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000423089	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000427034	DBD: Nuclear Hormone Receptor	Other: Hormone_recep

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:8114692 12511605
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:11114890 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:8020947, PMID:8114692 GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS - PMID:8114692 GO:0004882 androgen receptor activity TAS - PMID:9783588 GO:0004887 thyroid hormone receptor activity IEA - GO_REF:0000002
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Nitta2015		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Misc	HocoMoco		Direct
Misc	HocoMoco		Direct

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for NR1I3 (Nuclear receptor)