TF Info Page for NR1I3 (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: nuclear receptor subfamily 1 group I member 3 [Source:HGNC Symbol;Acc:HGNC:7969]
Entrez Summary This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000143257
External Link: CisBP
Interpro IPR000536; IPR001628; IPR001723; IPR001728; IPR008946; ;
Protein Domain: ENSP00000356958
Protein Domain: ENSP00000356960
Protein Domain: ENSP00000356961
Protein Domain: ENSP00000356962
Protein Domain: ENSP00000356963
Protein Domain: ENSP00000356965
Protein Domain: ENSP00000399361
Protein Domain: ENSP00000412672
Protein Domain: ENSP00000407446
Protein Domain: ENSP00000406493
Protein Domain: ENSP00000421374
Protein Domain: ENSP00000424345
Protein Domain: ENSP00000424934
Protein Domain: ENSP00000422982
Protein Domain: ENSP00000423666
Protein Domain: ENSP00000427175
Protein Domain: ENSP00000427600
Protein Domain: ENSP00000426292
Protein Domain: ENSP00000425417
Protein Domain: ENSP00000421588
Protein Domain: ENSP00000423089
Protein Domain: ENSP00000427034
Domain:
Protein: ENSP00000356958DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000356960DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000356961DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000356962DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000356963DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000356965DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000399361DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000412672DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000407446DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000406493DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000421374DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000424345DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000424934DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000422982DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000423666DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000427175DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000427600DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000426292DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000425417DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000421588DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000423089DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000427034DBD: Nuclear Hormone ReceptorOther: Hormone_recep

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:8114692 12511605
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IDA - PMID:11114890
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:8020947, PMID:8114692
GO:0004879
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
TAS - PMID:8114692
GO:0004882
androgen receptor activity
TAS - PMID:9783588
GO:0004887
thyroid hormone receptor activity
IEA - GO_REF:0000002
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXNitta2015Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
MiscHocoMocoDirect
MiscHocoMocoDirect

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution