TF Info Page for TBX19 (T-box)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: T-box 19 [Source:HGNC Symbol;Acc:HGNC:11596]
Entrez Summary This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000143178
External Link: CisBP
Interpro IPR001699; IPR002070; IPR008967; IPR018186;
Protein Domain: ENSP00000356795
Protein Domain: ENSP00000390731
Protein Domain: ENSP00000397540
Domain:
Protein: ENSP00000356795DBD: T-boxOther:
Protein: ENSP00000390731DBD: T-boxOther:
Protein: ENSP00000397540DBD: T-boxOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:11290323
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
HT-SELEXYin2017Inferred - T (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - T (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - T (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - T (82% AA Identity, Homo sapiens)
SELEXJASPARInferred - T (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - T (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - T (82% AA Identity, Homo sapiens)
MiscHOMERInferred - T (82% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - byn (74% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - byn (74% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - byn (74% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - byn (74% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution