TF Info Page for DMRTA2 (DM)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: DMRT like family A2 [Source:HGNC Symbol;Acc:HGNC:13908]
Entrez Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to act upstream of or within nervous system development and skeletal muscle cell differentiation. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Ensembl ID: ENSG00000142700
External Link: CisBP
Interpro IPR001275; IPR005173; IPR009060; ;
Protein Domain: ENSP00000399370
Protein Domain: ENSP00000383909
Domain:
Protein: ENSP00000399370DBD: DMOther: DMA
Protein: ENSP00000383909DBD: DMOther: DMA

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
PBMZoo_01Direct
TransfacTransfacLicense requiredInferred - Dmrta2 (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - dmrta2 (97% AA Identity, Xenopus tropicalis)
HT-SELEXNitta2015Inferred - dmrt99B (95% AA Identity, Drosophila melanogaster)
PBMTF_EvolutionUnpublished DataInferred - dmrt99B (95% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - dmrt99B (95% AA Identity, Drosophila melanogaster)
PBMCEPDInferred - dmd-5 (91% AA Identity, Caenorhabditis elegans)
HT-SELEXYin2017Inferred - DMRT3 (85% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DMRT3 (85% AA Identity, Homo sapiens)
PBMZoo_01Inferred - DMRT3 (85% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - DMRT3 (85% AA Identity, Homo sapiens)
PBMZoo_01Inferred - DMRT2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - DMRT2 (82% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution