TF Info Page for DMRTA2 (DM)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: DMRT like family A2 [Source:HGNC Symbol;Acc:HGNC:13908]
Entrez Summary NA
Ensembl ID: ENSG00000142700
External Link: CisBP
Interpro IPR001275; IPR005173; IPR009060; ;
Protein Domain: ENSP00000399370
Protein Domain: ENSP00000383909
Domain:
Protein: ENSP00000399370DBD: DMOther: DMA
Protein: ENSP00000383909DBD: DMOther: DMA

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
PBMZoo_01Direct
TransfacTransfacLicense requiredInferred - Dmrta2 (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - dmrta2 (97% AA Identity, Xenopus tropicalis)
HT-SELEXNitta2015Inferred - dmrt99B (95% AA Identity, Drosophila melanogaster)
PBMTF_EvolutionUnpublished DataInferred - dmrt99B (95% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - dmrt99B (95% AA Identity, Drosophila melanogaster)
PBMCEPDInferred - dmd-5 (91% AA Identity, Caenorhabditis elegans)
HT-SELEXYin2017Inferred - DMRT3 (85% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DMRT3 (85% AA Identity, Homo sapiens)
PBMZoo_01Inferred - DMRT3 (85% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - DMRT3 (85% AA Identity, Homo sapiens)
PBMZoo_01Inferred - DMRT2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - DMRT2 (82% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution