TF Info Page for FOXK2 (Forkhead)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: forkhead box K2 [Source:HGNC Symbol;Acc:HGNC:6036]
Entrez Summary The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000141568
External Link: CisBP
Interpro IPR000253; IPR001766; IPR008984; IPR018122;
Protein Domain: ENSP00000335677
Protein Domain: ENSP00000461540
Protein Domain: ENSP00000433167
Protein Domain: ENSP00000432663
Domain:
Protein: ENSP00000335677DBD: ForkheadOther: FHA
Protein: ENSP00000461540DBD: ForkheadOther:
Protein: ENSP00000433167DBD: ForkheadOther:
Protein: ENSP00000432663DBD: ForkheadOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:9065434
GO:0003700
sequence-specific DNA binding transcription factor activity
NAS - PMID:12402362
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMBadis09Inferred - Foxk1 (90% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Foxk1 (90% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Foxk1 (90% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - FOXK1 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXK1 (88% AA Identity, Homo sapiens)
PBMZoo_01Inferred - FOXK1 (88% AA Identity, Homo sapiens)
PBMZoo_01Inferred - SPU_025010 (85% AA Identity, Strongylocentrotus purpuratus)

Structure

Structure PDB 2C6Y

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution