TF Info Page for TP53 (p53)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source


Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998]
Entrez Summary This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Ensembl ID: ENSG00000141510
External Link: CisBP
Interpro IPR002117; IPR008967; IPR010991; IPR011615; IPR013872; ;
Protein Domain: ENSP00000269305
Protein Domain: ENSP00000352610
Protein Domain: ENSP00000410739
Protein Domain: ENSP00000391127
Protein Domain: ENSP00000391478
Protein Domain: ENSP00000398846
Protein Domain: ENSP00000484409
Protein Domain: ENSP00000481179
Protein Domain: ENSP00000478499
Protein Domain: ENSP00000423862
Protein Domain: ENSP00000458393
Protein Domain: ENSP00000478219
Protein Domain: ENSP00000480868
Protein Domain: ENSP00000477531
Protein Domain: ENSP00000482258
Protein Domain: ENSP00000481401
Protein Domain: ENSP00000484375
Protein Domain: ENSP00000482537
Protein Domain: ENSP00000481638
Protein Domain: ENSP00000482222
Protein: ENSP00000269305DBD: p53Other: P53_TAD, P53_tetramer
Protein: ENSP00000352610DBD: p53Other: P53_TAD
Protein: ENSP00000410739DBD: p53Other: P53_TAD
Protein: ENSP00000391127DBD: p53Other: P53_TAD
Protein: ENSP00000391478DBD: p53Other: P53_TAD, P53_tetramer
Protein: ENSP00000398846DBD: p53Other: P53_TAD
Protein: ENSP00000484409DBD: p53Other:
Protein: ENSP00000481179DBD: p53Other: P53_tetramer
Protein: ENSP00000478499DBD: p53Other:
Protein: ENSP00000423862DBD: p53Other: P53_TAD
Protein: ENSP00000458393DBD: p53Other:
Protein: ENSP00000478219DBD: p53Other: P53_tetramer
Protein: ENSP00000480868DBD: p53Other:
Protein: ENSP00000477531DBD: p53Other:
Protein: ENSP00000482258DBD: p53Other: P53_TAD
Protein: ENSP00000481401DBD: p53Other:
Protein: ENSP00000484375DBD: p53Other: P53_tetramer
Protein: ENSP00000482537DBD: p53Other: P53_tetramer
Protein: ENSP00000481638DBD: p53Other: P53_tetramer
Protein: ENSP00000482222DBD: p53Other:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IDA - PMID:24652652
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IDA - PMID:17146433
sequence-specific DNA binding transcription factor activity
IDA - PMID:18549481, PMID:7587074
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect


Structure PDB 1TSR

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution