TF Info Page for GATA6 (GATA)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: GATA binding protein 6 [Source:HGNC Symbol;Acc:HGNC:4174]
Entrez Summary This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
Ensembl ID: ENSG00000141448
External Link: CisBP
Interpro IPR000679; IPR008013;
Protein Domain: ENSP00000269216
Protein Domain: ENSP00000462313
Domain:
Protein: ENSP00000269216DBD: GATAOther: GATA-N
Protein: ENSP00000462313DBD: GATAOther: GATA-N

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_Transcription Factor Binding
tf co-factor binding_TF PPI_
PMIDS:14988427
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IMP - PMID:21127043
GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IBA - GO_REF:0000033
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:19666519
GO:0003705
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMBadis09Inferred - Gata6 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - GATA4 (90% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA4 (90% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Gata4 (90% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - GATA4 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA4 (90% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Gata4 (90% AA Identity, Mus musculus)
MiscHocoMocoInferred - GATA4 (90% AA Identity, Homo sapiens)
MiscHOMERInferred - Gata4 (90% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - GATA5 (87% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA5 (87% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA5 (87% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA5 (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA5 (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA5 (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA5 (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA5 (87% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gata5 (87% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Gata5 (87% AA Identity, Mus musculus)
MiscHocoMocoInferred - GATA5 (87% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - grn (84% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - grn (84% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - grn (84% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - GATA2 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA2 (82% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - pnr (82% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - pnr (82% AA Identity, Drosophila melanogaster)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-chipJASPARInferred - pnr (82% AA Identity, Drosophila melanogaster)
ChIP-seqmodENCODEInferred - pnr (82% AA Identity, Drosophila melanogaster)
MiscHocoMocoInferred - GATA2 (82% AA Identity, Homo sapiens)
MiscHOMERInferred - GATA2 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA3 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA3 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA3 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA3 (81% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gata3 (81% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - Gata3 (81% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - srp (81% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - srp (81% AA Identity, Drosophila melanogaster)
ChIP-seqENCODEInferred - GATA3 (81% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - GATA3 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (81% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GATA3 (81% AA Identity, Homo sapiens)
MiscHOMERInferred - Gata3 (81% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (81% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (81% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (81% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (81% AA Identity, Mus musculus)
MisciDMMPMMInferred - srp (81% AA Identity, Drosophila melanogaster)
ChIP-seqJASPARInferred - Gata1 (80% AA Identity, Mus musculus)
HT-SELEXJolma2010Inferred - GATA1 (78% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - GATA1 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA1 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA1 (78% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA1 (78% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA1 (78% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - GATA1 (78% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - GATA1 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (78% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GATA1 (78% AA Identity, Homo sapiens)
MiscHOMERInferred - GATA1 (78% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - elt-1 (75% AA Identity, Caenorhabditis elegans)
ChIP-seqmodENCODEInferred - elt-1 (75% AA Identity, Caenorhabditis elegans)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution