This gene encodes a transcription factor with multiple homeodomains
and zinc finger motifs, and regulates myogenic and neuronal differentiation.
The encoded protein suppresses expression of the alpha-fetoprotein gene by
binding to an AT-rich enhancer motif. The protein has also been shown to
negatively regulate c-Myb, and transactivate the cell cycle inhibitor
cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is
reported to function as a tumor suppressor in several cancers, and sequence
variants of this gene are also associated with atrial fibrillation. Multiple
transcript variants expressed from alternate promoters and encoding different
isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:1719379 GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS - PMID:1719379
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF