TF Info Page for NCOA2 (bHLH)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 2 Obligate heteromer | No motif | NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif. All are co-activators, collectively suggesting they might be obligate heteromers. |
Description
| Description: | nuclear receptor coactivator 2 [Source:HGNC Symbol;Acc:HGNC:7669] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000140396 | |
| External Link: | ||
| Interpro | IPR000014; IPR009110; IPR010011; IPR011598; IPR013767; IPR014920; IPR014935; IPR017426; | |
| Protein Domain: | ||
| Protein: ENSP00000399968 | DBD: bHLH | Other: DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA |
| Protein: ENSP00000429132 | DBD: bHLH | Other: DUF1518, Nuc_rec_co-act |
| Protein: ENSP00000430850 | DBD: bHLH | Other: |
| Protein: ENSP00000430348 | DBD: bHLH | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_Transcription Factor Binding tf co-factor binding_Co-activation_ PMIDS:14662770 15983373 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
x |
| CisBP considers it as a TF? | No |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
3a, decent circumstantial evidence for its role as |
| TF has conditional DNA-binding requirements |