Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Likely to be sequence specific TF
1 Monomer or homomultimer
No motif
Similar to HMG20B, which has an inferred motif from mouse.
Description
Description:
high mobility group 20A [Source:HGNC Symbol;Acc:HGNC:5001]
Entrez Summary
TBA
Ensembl ID:
ENSG00000140382
External Link:
T144097_1.02
Interpro
IPR009071 ; ;
Protein Domain:
Protein: ENSP00000336856DBD: HMGOther: DUF4763Protein: ENSP00000371133DBD: HMGOther: DUF4763Protein: ENSP00000452847DBD: HMGOther: DUF4763, IncA, Trans_reg_CProtein: ENSP00000452665DBD: HMGOther:
Previous Annotations
Source
Annotation
TF-CAT classification
No PMIDS:
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
x
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:10773667
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
{"regions": [{"startStyle": "curved", "end": 171, "endStyle": "curved", "aliStart": 103, "text": "HMG", "colour": "#228B22", "aliEnd": 170, "start": 103, "href": "http://pfam.xfam.org/family/PF00505.17", "type": "pfama", "display": "true", "metadata": {"end": 171, "description": "High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs.", "database": "PfamA", "aliStart": 103, "scoreName": "E-value", "accession": "PF00505.17", "start": 103, "score": 4.3e-19, "identifier": "HMG (high mobility group) box", "type": "DBD", "aliEnd": 170}}, {"startStyle": "jagged", "end": 294, "endStyle": "jagged", "aliStart": 224, "text": "DUF4763", "colour": "#9999ff", "aliEnd": 290, "start": 221, "href": "http://pfam.xfam.org/family/PF15960.3", "type": "pfama", "display": "true", "metadata": {"end": 294, "description": "This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 237 and 332 amino acids in length. There are two completely conserved residues (C and R) that may be functionally important.", "database": "PfamA", "aliStart": 224, "scoreName": "E-value", "accession": "PF15960.3", "start": 221, "score": 0.0098, "identifier": "Domain of unknown function (DUF4763)", "type": "DBD", "aliEnd": 290}}], "length": 348}
{"regions": [{"startStyle": "curved", "end": 171, "endStyle": "curved", "aliStart": 103, "text": "HMG", "colour": "#228B22", "aliEnd": 170, "start": 103, "href": "http://pfam.xfam.org/family/PF00505.17", "type": "pfama", "display": "true", "metadata": {"end": 171, "description": "High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs.", "database": "PfamA", "aliStart": 103, "scoreName": "E-value", "accession": "PF00505.17", "start": 103, "score": 4.3e-19, "identifier": "HMG (high mobility group) box", "type": "DBD", "aliEnd": 170}}, {"startStyle": "jagged", "end": 294, "endStyle": "jagged", "aliStart": 224, "text": "DUF4763", "colour": "#9999ff", "aliEnd": 290, "start": 221, "href": "http://pfam.xfam.org/family/PF15960.3", "type": "pfama", "display": "true", "metadata": {"end": 294, "description": "This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 237 and 332 amino acids in length. There are two completely conserved residues (C and R) that may be functionally important.", "database": "PfamA", "aliStart": 224, "scoreName": "E-value", "accession": "PF15960.3", "start": 221, "score": 0.0098, "identifier": "Domain of unknown function (DUF4763)", "type": "DBD", "aliEnd": 290}}], "length": 348}
{"regions": [{"startStyle": "jagged", "end": 76, "endStyle": "jagged", "aliStart": 47, "text": "Trans_reg_C", "colour": "#9999ff", "aliEnd": 65, "start": 36, "href": "http://pfam.xfam.org/family/PF00486.26", "type": "pfama", "display": "true", "metadata": {"end": 76, "description": NaN, "database": "PfamA", "aliStart": 47, "scoreName": "E-value", "accession": "PF00486.26", "start": 36, "score": 0.00073, "identifier": "Transcriptional regulatory protein, C terminal", "type": "DBD", "aliEnd": 65}}, {"startStyle": "jagged", "end": 112, "endStyle": "straight", "aliStart": 78, "text": "Trans_reg_C", "colour": "#9999ff", "aliEnd": 111, "start": 71, "href": "http://pfam.xfam.org/family/PF00486.26", "type": "pfama", "display": "true", "metadata": {"end": 112, "description": NaN, "database": "PfamA", "aliStart": 78, "scoreName": "E-value", "accession": "PF00486.26", "start": 71, "score": 0.00073, "identifier": "Transcriptional regulatory protein, C terminal", "type": "DBD", "aliEnd": 111}}, {"startStyle": "jagged", "end": 112, "endStyle": "jagged", "aliStart": 4, "text": "IncA", "colour": "#9999ff", "aliEnd": 65, "start": 1, "href": "http://pfam.xfam.org/family/PF04156.12", "type": "pfama", "display": "true", "metadata": {"end": 112, "description": "Chlamydia trachomatis is an obligate intracellular bacterium that develops within a parasitophorous vacuole termed an inclusion. The inclusion is non-fusogenic with lysosomes but intercepts lipids from a host cell exocytic pathway. Initiation of chlamydial development is concurrent with modification of the inclusion membrane by a set of C. trachomatis-encoded proteins collectively designated Incs. One of these Incs, IncA, is functionally associated with the homotypic fusion of inclusions [1]. This family probably includes members of the wider Inc family rather than just IncA. Members are usually either 2 or 4TM proteins.", "database": "PfamA", "aliStart": 4, "scoreName": "E-value", "accession": "PF04156.12", "start": 1, "score": 0.0014, "identifier": "IncA protein", "type": "DBD", "aliEnd": 65}}, {"startStyle": "jagged", "end": 66, "endStyle": "jagged", "aliStart": 4, "text": "DUF4763", "colour": "#9999ff", "aliEnd": 61, "start": 1, "href": "http://pfam.xfam.org/family/PF15960.3", "type": "pfama", "display": "true", "metadata": {"end": 66, "description": "This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 237 and 332 amino acids in length. There are two completely conserved residues (C and R) that may be functionally important.", "database": "PfamA", "aliStart": 4, "scoreName": "E-value", "accession": "PF15960.3", "start": 1, "score": 0.0032, "identifier": "Domain of unknown function (DUF4763)", "type": "DBD", "aliEnd": 61}}], "length": 119}