TF Info Page for ESR2 (Nuclear receptor)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | 100 perc ID - in vitro |
Description
| Description: | estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3468] | |||||||||||||||||||||||||||
| Entrez Summary | This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008] | |||||||||||||||||||||||||||
| Ensembl ID: | ENSG00000140009 | |||||||||||||||||||||||||||
| External Link: | CisBP | |||||||||||||||||||||||||||
| Interpro | IPR000536; IPR001628; IPR001723; IPR008946; IPR021064; IPR024178; IPR028355; ; | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000267525 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000343925 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000335551 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000452426 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000450699 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000450488 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000451582 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000351412 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000452485 | |||||||||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_Transactivation_ PMIDS:9058381 12047722 16484337 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:8769313 GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity NAS - PMID:9671811 GO:0038052 estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA - PMID:19126643 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA - PMID:10681512 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |