The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	100 perc ID - in vitro

Description

Description:	estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3468]
Entrez Summary	TBA
Ensembl ID:	ENSG00000140009
External Link:	T132762_1.02
Interpro	IPR000536; IPR001628; IPR001723; IPR008946; IPR021064; IPR024178; IPR028355; ;
Protein Domain:
Protein: ENSP00000267525	DBD: Nuclear Hormone Receptor	Other: ERbeta_N, Hormone_recep
Protein: ENSP00000343925	DBD: Nuclear Hormone Receptor	Other: ERbeta_N, Hormone_recep
Protein: ENSP00000335551	DBD: Nuclear Hormone Receptor	Other: ERbeta_N, Hormone_recep
Protein: ENSP00000452426	DBD: Nuclear Hormone Receptor	Other: ERbeta_N, Hormone_recep
Protein: ENSP00000450699	DBD: Nuclear Hormone Receptor	Other: ERbeta_N, Hormone_recep
Protein: ENSP00000450488	DBD: Nuclear Hormone Receptor	Other: ERbeta_N, Hormone_recep
Protein: ENSP00000451582	DBD: Nuclear Hormone Receptor	Other: ERbeta_N, Hormone_recep
Protein: ENSP00000351412	DBD: Nuclear Hormone Receptor	Other: ERbeta_N, Hormone_recep
Protein: ENSP00000452485	DBD: Nuclear Hormone Receptor	Other: ERbeta_N, Hormone_recep

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_Transactivation_ PMIDS:9058381 12047722 16484337
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:8769313 GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity NAS - PMID:9671811 GO:0038052 estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA - PMID:19126643 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA - PMID:10681512
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
ChIP-seq	JASPAR		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
Misc	HocoMoco		Direct
PBM	TF_Evolution	Unpublished Data	Inferred - Esr2 (100% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - ESR1 (92% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ESR1 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ESR1 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ESR1 (92% AA Identity, Homo sapiens)
PBM	DREAM_contest		Inferred - Esr1 (92% AA Identity, Mus musculus)
ChIP-seq	ENCODE		Inferred - ESR1 (92% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - ESR1 (92% AA Identity, Homo sapiens)
ChIP-seq	modENCODE		Inferred - ESR1 (92% AA Identity, Homo sapiens)
ChIP-seq	modENCODE		Inferred - ESR1 (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESR1 (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESR1 (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESR1 (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESR1 (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESR1 (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESR1 (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESR1 (92% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ESR1 (92% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ESR1 (92% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - Q6VU64_APLCA (84% AA Identity, Aplysia californica)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for ESR2 (Nuclear receptor)