TF Info Page for ETV6 (Ets)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: ETS variant 6 [Source:HGNC Symbol;Acc:HGNC:3495]
Entrez Summary This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
Ensembl ID: ENSG00000139083
External Link: CisBP
Interpro IPR000418; IPR003118; IPR013761; ;
Protein Domain: ENSP00000379658
Protein Domain: ENSP00000266427
Protein Domain: ENSP00000441463
Domain:
Protein: ENSP00000379658DBD: ETSOther: SAM_PNT
Protein: ENSP00000266427DBD: ETSOther:
Protein: ENSP00000441463DBD: ETSOther: SAM_PNT

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0001227
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IC - GO_REF:0000036
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:7761424
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
PBMWei10Inferred - Etv6 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ETV7 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV7 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV7 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV7 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETV7 (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV7 (82% AA Identity, Homo sapiens)

Structure

Structure PDB 4MHG

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution