TF Info Page for CARF (Unknown)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | Transfac-only motif. Major evidence is found in (PMID: 11832226). Cloned by Y1H and binding demonstrated by gel-shift. Mutant probes do not compete. DNA binding ability seems solid but motif is sketchy. |
Description
| Description: | calcium responsive transcription factor [Source:HGNC Symbol;Acc:HGNC:14435] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000138380 | |
| External Link: | ||
| Interpro | IPR029309; | |
| Protein Domain: | ||
| Protein: ENSP00000384006 | DBD: Other | Other: ALS2CR8 |
| Protein: ENSP00000415948 | DBD: Other | Other: ALS2CR8 |
| Protein: ENSP00000414644 | DBD: Other | Other: ALS2CR8 |
| Protein: ENSP00000416812 | DBD: Other | Other: ALS2CR8 |
| Protein: ENSP00000316224 | DBD: Other | Other: ALS2CR8 |
| Protein: ENSP00000416160 | DBD: Other | Other: ALS2CR8 |
| Protein: ENSP00000396221 | DBD: Other | Other: ALS2CR8 |
| Protein: ENSP00000391617 | DBD: Other | Other: |
| Protein: ENSP00000387785 | DBD: Other | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
No PMIDS: |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
No |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:11832226 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements |