TF Info Page for CARF (Unknown)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Transfac-only motif. Major evidence is found in (PMID: 11832226). Cloned by Y1H and binding demonstrated by gel-shift. Mutant probes do not compete. DNA binding ability seems solid but motif is sketchy.


Description: calcium responsive transcription factor [Source:HGNC Symbol;Acc:HGNC:14435]
Entrez Summary NA
Ensembl ID: ENSG00000138380
External Link: CisBP
Interpro IPR029309;
Protein Domain: ENSP00000384006
Protein Domain: ENSP00000415948
Protein Domain: ENSP00000414644
Protein Domain: ENSP00000416812
Protein Domain: ENSP00000316224
Protein Domain: ENSP00000416160
Protein Domain: ENSP00000396221
Protein Domain: ENSP00000391617
Protein Domain: ENSP00000387785
Protein: ENSP00000384006DBD: OtherOther: ALS2CR8
Protein: ENSP00000415948DBD: OtherOther: ALS2CR8
Protein: ENSP00000414644DBD: OtherOther: ALS2CR8
Protein: ENSP00000416812DBD: OtherOther: ALS2CR8
Protein: ENSP00000316224DBD: OtherOther: ALS2CR8
Protein: ENSP00000416160DBD: OtherOther: ALS2CR8
Protein: ENSP00000396221DBD: OtherOther: ALS2CR8
Protein: ENSP00000391617DBD: OtherOther:
Protein: ENSP00000387785DBD: OtherOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
sequence-specific DNA binding transcription factor activity
IDA - PMID:11832226
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution