Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Known motif
1 Monomer or homomultimer
In vivo/Misc source
Only known motifs are from Transfac or HocoMoco - origin is uncertain
Description
Description:
signal transducer and activator of transcription 4 [Source:HGNC Symbol;Acc:HGNC:11365]
Entrez Summary
TBA
Ensembl ID:
ENSG00000138378
External Link:
T148408_1.02
Interpro
IPR000980 ; IPR008967 ; IPR013799 ; IPR013800 ; IPR013801 ; IPR015155 ; IPR015988 ; ;
Protein Domain:
Protein: ENSP00000351255DBD: STATOther: SH2, STAT_alpha, STAT_intProtein: ENSP00000376134DBD: STATOther: SH2, STAT_alpha, STAT_intProtein: ENSP00000412397DBD: STATOther: STAT_int
Previous Annotations
Source
Annotation
TF-CAT classification
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:12372421 17304212
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000002
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements
Requires_Phosphorylation
DNA-Binding
Published Motif Data
Structure
Experimental History
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{"regions": [{"startStyle": "curved", "end": 562, "endStyle": "curved", "aliStart": 316, "text": "STAT", "colour": "#228B22", "aliEnd": 562, "start": 316, "href": "http://pfam.xfam.org/family/PF02864.13", "type": "pfama", "display": "true", "metadata": {"end": 562, "description": "STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain Pfam:PF00017.", "database": "PfamA", "aliStart": 316, "scoreName": "E-value", "accession": "PF02864.13", "start": 316, "score": 9.999999999999998e-74, "identifier": "STAT protein, DNA binding domain", "type": "DBD", "aliEnd": 562}}, {"startStyle": "straight", "end": 314, "endStyle": "straight", "aliStart": 140, "text": "STAT_alpha", "colour": "#9999ff", "aliEnd": 313, "start": 140, "href": "http://pfam.xfam.org/family/PF01017.18", "type": "pfama", "display": "true", "metadata": {"end": 314, "description": "STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.", "database": "PfamA", "aliStart": 140, "scoreName": "E-value", "accession": "PF01017.18", "start": 140, "score": 2e-53, "identifier": "STAT protein, all-alpha domain", "type": "DBD", "aliEnd": 313}}, {"startStyle": "straight", "end": 120, "endStyle": "straight", "aliStart": 2, "text": "STAT_int", "colour": "#9999ff", "aliEnd": 119, "start": 2, "href": "http://pfam.xfam.org/family/PF02865.15", "type": "pfama", "display": "true", "metadata": {"end": 120, "description": "STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.", "database": "PfamA", "aliStart": 2, "scoreName": "E-value", "accession": "PF02865.15", "start": 2, "score": 3.8e-38, "identifier": "STAT protein, protein interaction domain", "type": "DBD", "aliEnd": 119}}, {"startStyle": "straight", "end": 645, "endStyle": "jagged", "aliStart": 573, "text": "SH2", "colour": "#9999ff", "aliEnd": 627, "start": 569, "href": "http://pfam.xfam.org/family/PF00017.22", "type": "pfama", "display": "true", "metadata": {"end": 645, "description": NaN, "database": "PfamA", "aliStart": 573, "scoreName": "E-value", "accession": "PF00017.22", "start": 569, "score": 1.7e-11, "identifier": "SH2 domain", "type": "DBD", "aliEnd": 627}}], "length": 749}
{"regions": [{"startStyle": "straight", "end": 79, "endStyle": "jagged", "aliStart": 2, "text": "STAT_int", "colour": "#9999ff", "aliEnd": 78, "start": 2, "href": "http://pfam.xfam.org/family/PF02865.15", "type": "pfama", "display": "true", "metadata": {"end": 79, "description": "STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.", "database": "PfamA", "aliStart": 2, "scoreName": "E-value", "accession": "PF02865.15", "start": 2, "score": 8.7e-27, "identifier": "STAT protein, protein interaction domain", "type": "DBD", "aliEnd": 78}}], "length": 79}