Also contains a Ku C terminal like domain that is thought to be involved in DNA-damage repair pathways.
Description
Description:
zinc finger protein 365 [Source:HGNC Symbol;Acc:HGNC:18194]
Entrez Summary
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This gene encodes a zinc finger protein that may play a role in the
repair of DNA damage and maintenance of genome stability. The N-terminal C2H2
zinc finger motif is required to form a protein complex with PARP1 and MRE11,
which are known to be involved in the restart of stalled DNA replication
forks. A mutation in this gene may be associated with breast cancer
susceptibility. [provided by RefSeq, Mar 2020]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF