TF Info Page for FOXP4 (Forkhead)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: forkhead box P4 [Source:HGNC Symbol;Acc:HGNC:20842]
Entrez Summary This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000137166
External Link: CisBP
Interpro IPR001766; ;
Protein Domain: ENSP00000309823
Protein Domain: ENSP00000362148
Protein Domain: ENSP00000362154
Protein Domain: ENSP00000393704
Domain:
Protein: ENSP00000309823DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000362148DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000362154DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000393704DBD: ForkheadOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:14701752
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Inferred - FOXP1 (90% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXP1 (90% AA Identity, Homo sapiens)
PBMZoo_01Inferred - FOXP1 (90% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Foxp1 (90% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - FOXP1 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXP1 (90% AA Identity, Homo sapiens)
MiscHOMERInferred - FOXP1 (90% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - FOXP2 (85% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Foxp2 (85% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - FOXP2 (85% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FOXP2 (85% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - FoxP (71% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution