The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif		Homodimerizes on GTCTAGAC sequence (EMSA) (PMID: 9824161)

Description

Description:	SKI-like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897]
Entrez Summary	TBA
Ensembl ID:	ENSG00000136603
External Link:
Interpro	IPR003380; IPR009061; IPR010919; IPR014890;
Protein Domain:
Protein: ENSP00000259119	DBD: Other	Other: Ski_Sno, c-SKI_SMAD_bind
Protein: ENSP00000400193	DBD: Other	Other: Ski_Sno, c-SKI_SMAD_bind
Protein: ENSP00000415243	DBD: Other	Other: Ski_Sno, c-SKI_SMAD_bind
Protein: ENSP00000406520	DBD: Other	Other: Ski_Sno, c-SKI_SMAD_bind

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_Transcription Factor Binding tf co-factor binding_DNA Binding Transactivation_ PMIDS:9824161 9927733 10531062
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	No
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:10531062
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "straight", "end": 235, "endStyle": "straight", "aliStart": 131, "text": "Ski_Sno", "colour": "#9999ff", "aliEnd": 234, "start": 128, "href": "http://pfam.xfam.org/family/PF02437.15", "type": "pfama", "display": "true", "metadata": {"end": 235, "description": "This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [1]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].", "database": "PfamA", "aliStart": 131, "scoreName": "E-value", "accession": "PF02437.15", "start": 128, "score": 2.3e-43, "identifier": "SKI/SNO/DAC family", "type": "DBD", "aliEnd": 234}}, {"startStyle": "straight", "end": 355, "endStyle": "straight", "aliStart": 261, "text": "c-SKI_SMAD_bind", "colour": "#9999ff", "aliEnd": 355, "start": 261, "href": "http://pfam.xfam.org/family/PF08782.8", "type": "pfama", "display": "true", "metadata": {"end": 355, "description": "c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1].  This domain binds to Smad4 [2]", "database": "PfamA", "aliStart": 261, "scoreName": "E-value", "accession": "PF08782.8", "start": 261, "score": 5.999999999999999e-37, "identifier": "c-SKI Smad4 binding domain", "type": "DBD", "aliEnd": 355}}], "length": 685}

{"regions": [{"startStyle": "straight", "end": 235, "endStyle": "straight", "aliStart": 131, "text": "Ski_Sno", "colour": "#9999ff", "aliEnd": 234, "start": 128, "href": "http://pfam.xfam.org/family/PF02437.15", "type": "pfama", "display": "true", "metadata": {"end": 235, "description": "This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [1]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].", "database": "PfamA", "aliStart": 131, "scoreName": "E-value", "accession": "PF02437.15", "start": 128, "score": 2.0999999999999997e-43, "identifier": "SKI/SNO/DAC family", "type": "DBD", "aliEnd": 234}}, {"startStyle": "straight", "end": 355, "endStyle": "straight", "aliStart": 261, "text": "c-SKI_SMAD_bind", "colour": "#9999ff", "aliEnd": 355, "start": 261, "href": "http://pfam.xfam.org/family/PF08782.8", "type": "pfama", "display": "true", "metadata": {"end": 355, "description": "c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1].  This domain binds to Smad4 [2]", "database": "PfamA", "aliStart": 261, "scoreName": "E-value", "accession": "PF08782.8", "start": 261, "score": 5.3e-37, "identifier": "c-SKI Smad4 binding domain", "type": "DBD", "aliEnd": 355}}], "length": 639}

{"regions": [{"startStyle": "straight", "end": 215, "endStyle": "straight", "aliStart": 111, "text": "Ski_Sno", "colour": "#9999ff", "aliEnd": 214, "start": 108, "href": "http://pfam.xfam.org/family/PF02437.15", "type": "pfama", "display": "true", "metadata": {"end": 215, "description": "This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [1]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].", "database": "PfamA", "aliStart": 111, "scoreName": "E-value", "accession": "PF02437.15", "start": 108, "score": 2.2e-43, "identifier": "SKI/SNO/DAC family", "type": "DBD", "aliEnd": 214}}, {"startStyle": "straight", "end": 335, "endStyle": "straight", "aliStart": 241, "text": "c-SKI_SMAD_bind", "colour": "#9999ff", "aliEnd": 335, "start": 241, "href": "http://pfam.xfam.org/family/PF08782.8", "type": "pfama", "display": "true", "metadata": {"end": 335, "description": "c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1].  This domain binds to Smad4 [2]", "database": "PfamA", "aliStart": 241, "scoreName": "E-value", "accession": "PF08782.8", "start": 241, "score": 5.6e-37, "identifier": "c-SKI Smad4 binding domain", "type": "DBD", "aliEnd": 335}}], "length": 665}

TF Info Page for SKIL (Unknown)