TF Info Page for GATA4 (GATA)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | GATA binding protein 4 [Source:HGNC Symbol;Acc:HGNC:4173] | |||||||||||||||
| Entrez Summary | This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] | |||||||||||||||
| Ensembl ID: | ENSG00000136574 | |||||||||||||||
| External Link: | CisBP | |||||||||||||||
| Interpro | IPR000679; IPR008013; IPR016375; ; | |||||||||||||||
| Protein Domain: | ENSP00000435712 | |||||||||||||||
| Protein Domain: | ENSP00000473671 | |||||||||||||||
| Protein Domain: | ENSP00000473598 | |||||||||||||||
| Protein Domain: | ENSP00000432278 | |||||||||||||||
| Protein Domain: | ENSP00000435043 | |||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:8455608 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:9312027 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |