TF Info Page for TBR1 (T-box)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: T-box, brain 1 [Source:HGNC Symbol;Acc:HGNC:11590]
Entrez Summary This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015]
Ensembl ID: ENSG00000136535
External Link: CisBP
Interpro IPR001699; IPR008967; IPR018186; ;
Protein Domain: ENSP00000374205
Protein Domain: ENSP00000387023
Protein Domain: ENSP00000393934
Protein: ENSP00000374205DBD: T-boxOther: T-box_assoc
Protein: ENSP00000387023DBD: T-boxOther: T-box_assoc
Protein: ENSP00000393934DBD: T-boxOther: T-box_assoc

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_Transcription Factor Binding
tf co-factor binding
sequence-specific_DNA Binding_
PMIDS:10749215 11239428 15634788
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
PBMSebePedros2013Inferred - Tbr1 (100% AA Identity, Mus musculus)
HT-SELEXJolma2010Inferred - EOMES (85% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - EOMES (85% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EOMES (85% AA Identity, Homo sapiens)
PBMBadis09Inferred - Eomes (85% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - EOMES (85% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EOMES (85% AA Identity, Homo sapiens)
MiscHOMERInferred - EOMES (85% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TBX21 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TBX21 (71% AA Identity, Homo sapiens)
MiscHOMERInferred - Tbx21 (71% AA Identity, Mus musculus)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution