Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Likely to be sequence specific TF
1 Monomer or homomultimer
No motif
Description
Description:
lysine acetyltransferase 7 [Source:HGNC Symbol;Acc:HGNC:17016]
Entrez Summary
TBA
Ensembl ID:
ENSG00000136504
External Link:
Interpro
IPR002515 ; IPR002717 ; IPR016181 ; ;
Protein Domain:
Protein: ENSP00000259021DBD: C2H2 ZF Containing ProteinsOther: MOZ_SASProtein: ENSP00000398961DBD: C2H2 ZF Containing ProteinsOther: MOZ_SASProtein: ENSP00000409477DBD: C2H2 ZF Containing ProteinsOther: MOZ_SASProtein: ENSP00000413415DBD: C2H2 ZF Containing ProteinsOther: MOZ_SASProtein: ENSP00000424577DBD: C2H2 ZF Containing ProteinsOther: MOZ_SASProtein: ENSP00000423385DBD: C2H2 ZF Containing ProteinsOther: MOZ_SAS
Previous Annotations
Source
Annotation
TF-CAT classification
No PMIDS:
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
x
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000002
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
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{"regions": [{"startStyle": "curved", "end": 212, "endStyle": "curved", "aliStart": 184, "text": "zfC2HC", "colour": "#2cb42c", "aliEnd": 212, "start": 184, "href": "http://pfam.xfam.org/family/PF01530.16", "type": "pfama", "display": "true", "metadata": {"end": 212, "description": "This is a DNA binding zinc finger domain.", "database": "PfamA", "aliStart": 184, "scoreName": "E-value", "accession": "PF01530.16", "start": 184, "score": 6.2e-14, "identifier": "Zinc finger, C2HC type", "type": "DBD", "aliEnd": 212}}, {"startStyle": "straight", "end": 541, "endStyle": "straight", "aliStart": 363, "text": "MOZ_SAS", "colour": "#9999ff", "aliEnd": 540, "start": 363, "href": "http://pfam.xfam.org/family/PF01853.16", "type": "pfama", "display": "true", "metadata": {"end": 541, "description": "This region of these proteins has been suggested to be homologous to acetyltransferases [1].", "database": "PfamA", "aliStart": 363, "scoreName": "E-value", "accession": "PF01853.16", "start": 363, "score": 3.5e-86, "identifier": "MOZ/SAS family", "type": "DBD", "aliEnd": 540}}], "length": 582}
{"regions": [{"startStyle": "curved", "end": 56, "endStyle": "curved", "aliStart": 28, "text": "zfC2HC", "colour": "#2cb42c", "aliEnd": 56, "start": 28, "href": "http://pfam.xfam.org/family/PF01530.16", "type": "pfama", "display": "true", "metadata": {"end": 56, "description": "This is a DNA binding zinc finger domain.", "database": "PfamA", "aliStart": 28, "scoreName": "E-value", "accession": "PF01530.16", "start": 28, "score": 4.2999999999999993e-14, "identifier": "Zinc finger, C2HC type", "type": "DBD", "aliEnd": 56}}, {"startStyle": "straight", "end": 385, "endStyle": "straight", "aliStart": 207, "text": "MOZ_SAS", "colour": "#9999ff", "aliEnd": 384, "start": 207, "href": "http://pfam.xfam.org/family/PF01853.16", "type": "pfama", "display": "true", "metadata": {"end": 385, "description": "This region of these proteins has been suggested to be homologous to acetyltransferases [1].", "database": "PfamA", "aliStart": 207, "scoreName": "E-value", "accession": "PF01853.16", "start": 207, "score": 1.8e-86, "identifier": "MOZ/SAS family", "type": "DBD", "aliEnd": 384}}], "length": 426}
{"regions": [{"startStyle": "jagged", "end": 73, "endStyle": "curved", "aliStart": 53, "text": "zfC2HC", "colour": "#2cb42c", "aliEnd": 73, "start": 52, "href": "http://pfam.xfam.org/family/PF01530.16", "type": "pfama", "display": "true", "metadata": {"end": 73, "description": "This is a DNA binding zinc finger domain.", "database": "PfamA", "aliStart": 53, "scoreName": "E-value", "accession": "PF01530.16", "start": 52, "score": 5.1e-07, "identifier": "Zinc finger, C2HC type", "type": "DBD", "aliEnd": 73}}, {"startStyle": "straight", "end": 432, "endStyle": "straight", "aliStart": 254, "text": "MOZ_SAS", "colour": "#9999ff", "aliEnd": 431, "start": 254, "href": "http://pfam.xfam.org/family/PF01853.16", "type": "pfama", "display": "true", "metadata": {"end": 432, "description": "This region of these proteins has been suggested to be homologous to acetyltransferases [1].", "database": "PfamA", "aliStart": 254, "scoreName": "E-value", "accession": "PF01853.16", "start": 254, "score": 2.1999999999999998e-86, "identifier": "MOZ/SAS family", "type": "DBD", "aliEnd": 431}}], "length": 473}
{"regions": [{"startStyle": "jagged", "end": 132, "endStyle": "curved", "aliStart": 113, "text": "zfC2HC", "colour": "#2cb42c", "aliEnd": 132, "start": 113, "href": "http://pfam.xfam.org/family/PF01530.16", "type": "pfama", "display": "true", "metadata": {"end": 132, "description": "This is a DNA binding zinc finger domain.", "database": "PfamA", "aliStart": 113, "scoreName": "E-value", "accession": "PF01530.16", "start": 113, "score": 2.3e-06, "identifier": "Zinc finger, C2HC type", "type": "DBD", "aliEnd": 132}}, {"startStyle": "straight", "end": 461, "endStyle": "straight", "aliStart": 283, "text": "MOZ_SAS", "colour": "#9999ff", "aliEnd": 460, "start": 283, "href": "http://pfam.xfam.org/family/PF01853.16", "type": "pfama", "display": "true", "metadata": {"end": 461, "description": "This region of these proteins has been suggested to be homologous to acetyltransferases [1].", "database": "PfamA", "aliStart": 283, "scoreName": "E-value", "accession": "PF01853.16", "start": 283, "score": 2.5e-86, "identifier": "MOZ/SAS family", "type": "DBD", "aliEnd": 460}}], "length": 502}
{"regions": [{"startStyle": "jagged", "end": 73, "endStyle": "curved", "aliStart": 53, "text": "zfC2HC", "colour": "#2cb42c", "aliEnd": 73, "start": 52, "href": "http://pfam.xfam.org/family/PF01530.16", "type": "pfama", "display": "true", "metadata": {"end": 73, "description": "This is a DNA binding zinc finger domain.", "database": "PfamA", "aliStart": 53, "scoreName": "E-value", "accession": "PF01530.16", "start": 52, "score": 4.8e-07, "identifier": "Zinc finger, C2HC type", "type": "DBD", "aliEnd": 73}}, {"startStyle": "straight", "end": 402, "endStyle": "straight", "aliStart": 224, "text": "MOZ_SAS", "colour": "#9999ff", "aliEnd": 401, "start": 224, "href": "http://pfam.xfam.org/family/PF01853.16", "type": "pfama", "display": "true", "metadata": {"end": 402, "description": "This region of these proteins has been suggested to be homologous to acetyltransferases [1].", "database": "PfamA", "aliStart": 224, "scoreName": "E-value", "accession": "PF01853.16", "start": 224, "score": 1.8999999999999996e-86, "identifier": "MOZ/SAS family", "type": "DBD", "aliEnd": 401}}], "length": 443}