hes related family bHLH transcription factor with YRPW motif 2 [Source:HGNC Symbol;Acc:HGNC:4881]
Entrez Summary
This gene encodes a member of the hairy and enhancer of
split-related (HESR) family of basic helix-loop-helix (bHLH)-type
transcription factors. The encoded protein forms homo- or hetero-dimers that
localize to the nucleus and interact with a histone deacetylase complex to
repress transcription. Expression of this gene is induced by the Notch signal
transduction pathway. Two similar and redundant genes in mouse are required
for embryonic cardiovascular development, and are also implicated in
neurogenesis and somitogenesis. Alternatively spliced transcript variants
have been found, but their biological validity has not been determined.
[provided by RefSeq, Jul 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity ISS - GO_REF:0000024 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:15485867
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF