TF Info Page for ELF5 (Ets)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: E74 like ETS transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3320]
Entrez Summary The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Ensembl ID: ENSG00000135374
External Link: CisBP
Interpro IPR000418; IPR003118; IPR013761; ;
Protein Domain: ENSP00000257832
Protein Domain: ENSP00000311010
Protein Domain: ENSP00000407589
Protein Domain: ENSP00000436386
Domain:
Protein: ENSP00000257832DBD: ETSOther: SAM_PNT
Protein: ENSP00000311010DBD: ETSOther: SAM_PNT
Protein: ENSP00000407589DBD: ETSOther:
Protein: ENSP00000436386DBD: ETSOther: SAM_PNT

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:9840936 10506207
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMWei10Inferred - Elf5 (100% AA Identity, Mus musculus)
PBMBadis09Inferred - Ehf (69% AA Identity, Mus musculus)
PBMWei10Inferred - Ehf (69% AA Identity, Mus musculus)
HT-SELEXJolma2010Inferred - EHF (67% AA Identity, Homo sapiens)
SELEXJASPARInferred - EHF (67% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EHF (67% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EHF (67% AA Identity, Homo sapiens)
MiscHOMERInferred - EHF (67% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELF3 (65% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELF3 (65% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELF3 (65% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELF3 (65% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELF3 (65% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELF3 (65% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELF3 (65% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELF3 (65% AA Identity, Homo sapiens)
PBMBadis09Inferred - Elf3 (65% AA Identity, Mus musculus)
PBMWei10Inferred - Elf3 (65% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ELF3 (65% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELF3 (65% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELF3 (65% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution