TF Info Page for DMTF1 (Myb/SANT)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Contains 2 Myb DBDs. Binds to CCCG(G/T)ATGT (PMID: 8887674) |
Description
| Description: | cyclin D binding myb like transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:14603] | |||||||||||||||||||||
| Entrez Summary | This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] | |||||||||||||||||||||
| Ensembl ID: | ENSG00000135164 | |||||||||||||||||||||
| External Link: | CisBP | |||||||||||||||||||||
| Interpro | IPR001005; IPR009057; IPR017877; IPR017930; | |||||||||||||||||||||
| Protein Domain: | ENSP00000332171 | |||||||||||||||||||||
| Protein Domain: | ENSP00000378193 | |||||||||||||||||||||
| Protein Domain: | ENSP00000416499 | |||||||||||||||||||||
| Protein Domain: | ENSP00000412532 | |||||||||||||||||||||
| Protein Domain: | ENSP00000463239 | |||||||||||||||||||||
| Protein Domain: | ENSP00000410288 | |||||||||||||||||||||
| Protein Domain: | ENSP00000461920 | |||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:8425553 9786929 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:10095122 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
3a, decent circumstantial evidence for its role as |
| TF has conditional DNA-binding requirements |